Table 4: Tobacco and alcohol status in head and neck cancer cases by HPV E6/E7 1,2 and tumor HPV status1 ( 𝑁 = 2 0 4 ).

Risk factorE6/E7 positiveE6/E7 negativeOR (95% CI)Tumor positive3Tumor negative3OR (95% CI)
N (%)N (%)N (%)N (%)

Prevalence52 (25.5)152 (74.5)53 (26.0)151 (74.0)
Tumor site
 Oral cavity14 (26.9)131 (86.2)1.019 (35.9)126 (83.4)1.0
 Oropharynx38 (73.1)21 (13.8)17.3 (7.4–40.5)34 (64.2)25 (16.6)8.8 (4.1–19.0)
Tobacco4
 Never8 (15.7)49 (32.5)1.09 (17.3)48 (32.0)1.0
 ≤3020 (39.2)37 (24.5)2.1 (0.8–5.7)23 (44.2)34 (22.7)3.0 (1.2–7.5)
 >3023 (45.1)65 (43.0)1.1 (0.4–3.1)20 (38.5)68 (45.3)1.2 (0.5–3.4)
≤30 versus >30 1.9 (0.8–4.2)2.3 (1.1–5.1)
Alcohol5
 Never7 (13.7)51 (33.6)1.08 (15.4)50 (33.1)1.0
 ≤2124 (47.1)56 (36.8)2.3 (0.8–6.2)27 (51.9)53 (35.1)3.0 (1.2–7.8)
 >2120 (39.2)45 (29.6)2.1 (0.7–6.4)17 (32.7)48 (31.8)2.2 (0.7–6.8)
≤21 versus >21 1.1 (0.5–2.5)3 (5.8)10 (6.7)1.3 (0.6–3.0)
Tobacco/alcohol6
 Never//never4 (7.8)38 (25.2)1.01.0
 ≤30/≤2113 (25.5)21 (13.9)3.2 (0.9–12.0)15 (28.9)19 (12.7)4.2 (1.2–14.0)
 ≤30/>214 (7.8)10 (6.6)1.8 (0.3–9.3)5 (9.6)9 (6.0)2.6 (0.6–11.8)
 >30/≤218 (15.7)24 (15.9)1.6 (0.4–6.7)9 (17.3)23 (15.3)1.9 (0.5–6.8)
 >30/>2115 (29.4)34 (22.5)1.6 (0.4–5.9)11 (21.2)38 (25.3)1.2 (0.3–4.2)

1Percentages based on available data; 2HPV E6/E7 seronegative for HPV-16, and -33; HPV E6/E7 seropositive for HPV-16 and/or -33; 3DNA negative for all HPV DNA types; DNA positive for HPV-16 and/or -33; 4adjusted for age (continuous), gender, tumor site (oral cavity, oropharynx), and average drinks/week (continuous); 5adjusted for age (continuous), gender, tumor site (oral cavity, oropharynx), and tobacco pack-years (continuous); 6adjusted for age (continuous) and gender.