Complex Etiology Underlies Risk and Survival in Head and Neck Cancer Human Papillomavirus, Tobacco, and Alcohol: A Case for Multifactor Disease

Table 5

Adjusted¹ hazard ratios for disease-specific and recurrence free survival.²

Risk Factors	Oral cavity				Oropharynx
	Disease-specific Survival^1		Recurrence-free survival^1		Disease-specific survival^1		Recurrence-free survival^1
	HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)
Patients with HPV serology (𝑁=182)
		𝑁=116		𝑁=96		𝑁=52		𝑁=43
E6 and/or E7	n		n		n		n
Negative	103 (88.8)	1.3 (0.4–4.2)	86 (89.6)	1.1 (0.3–3.6)	16 (30.8)	5.7 (1.7–20.0)	13 (30.2)	6.7 (1.7–26.1)
Positive	13 (11.2)	1.0	10 (10.4)	1.0	36 (69.2)	1.0	30 (69.8)	1.0
Age^2		1.02 (1.0–1.1)		1.02 (1.0–1.04)		1.04 (0.96–1.1)		1.03 (0.95–1.1)
Stage
0/I/II		1.0		1.0		1.0		1.0
III/IV		7.9 (2.8–22.5)		1.5 (0.7–3.1)		1.5 (0.2–11.4)^3		1.3 (0.03–58.8)
Patients with both HPV tumor and serology (𝑁=157)
		𝑁=100		𝑁=88		𝑁=44		𝑁=39
E6 and/or E7	n		n		n		n
Negative	89 (89.0)	1.4 (0.4–4.5)	80 (90.9)	1.1 (0.3–3.5)	14 (31.8)	4.2 (1.2–15.1)	12 (30.8)	10.4 (2.4–52.4)
Positive	11 (11.0)	1.0	8 (9.1)	1.0	30 (68.2)	1.0	27 (69.2)	1.0
HPV tumor status
Negative	88 (88.0)	0.8 (0.3–2.0)	78 (88.6)	0.5 (0.2–1.3)	17 (38.6)	3.0 (0.9–10.7)	15 (38.5)	7.3 (1.5–36.4)
High Risk	12 (12.0)	1.0	10 (11.4)	1.0	27 (61.4)	1.0	24 (61.5)	1.0

¹Adjusted for stage and continuous age; ²in years; ³odds ratio Logit estimator adjusted for stage and categorical age.