DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression
Figure 3
pChk2 immunoreactivity in ovarian tissues and different histologic subtypes of ovarian carcinomas. (a) pChk2 staining is undetectable in ovarian surface epithelium (OSE), cystadenoma (Cyst), normal fallopian tube (NFT). (b) serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC), are negative for pChk2 staining. In contrast, a high-grade serous carcinoma (HGSC) is diffusely positive for pChk2.
