Journal of Oncology / 2012 / Article / Tab 4 / Clinical Study
Retrospective Study of Selective Submandibular Neck Dissection versus Radical Neck Dissection for N0 or N1 Necks in Level I Patients with Oral Squamous Cell Carcinoma Table 4 Cox’s proportional hazard model with univariate and multivariate analysis in clinically N1 necks.
Regional control Disease specific survival Univariate Multivariate Univariate Multivariate Hazard ratio (95% CI) P valueHazard ratio (95% CI) P valueHazard ratio (95% CI) P valueHazard ratio (95% CI) P valueType of neck dissection RND/SMND 0.889 (0.289–2.412) 0.838 0.897 (0.224–2.263) 0.962 0.989 (0.346–3.086) 0.948 0.898 (0.209–2.225) 0.796 Clinical tumor stage T3, 4/T1, 2 2.857 (0.794–5.941) 0.086 3.112 (0.990–10.434) 0.040 2.465 (1.107–5.261) 0.071 Primary tumor site Tongue 1.129 (0.443–2.676) 0.877 1.024 (0.497–2.311) 0.798 Tumor depth (tongue) ≧ 4 mm 1.857 (0.665–3.838) 0.101 1.414 (0.736–4.109) 0.385 Poorly or moderately differentiated 2.238 (0.733–4.496) 0.163 3.212 (0.876–7.769) 0.073 Mode of invasion Grade 4 3.250 (1.805–7.727) 0.041 2.966 (0.849–7.330) 0.760 3.814 (1.018–9.012) 0.036 3.145 (1.883–7.516) 0.240 Neoadjuvant chemoradiotherapy 0.263 (0.092–0.706) 0.045 0.195 (0.087–0.451) 0.013 0.312 (0.152–0.942) 0.039 0.232 (0.090–0.596) 0.018 Pathological nodal stage pN2 3.750 (1.825–7.586) 0.031 6.869 (2.681–14.011) 0.022 5.847 (1.888–10.719) 0.005 6.989 (2.428–12.111) 0.004 Extracapsular spread 6.224 (2.484–12..234) 0.002 11.342 (5.880–20.419) <0.001 9.868 (4.510–18.225) <0.001 12.767 (6.926–19.446) <0.001 Adjuvant chemoradiotherapy 1.743 (0.454–4.379) 0.473 2.637 (0.720–9.499) 0.129
SMND: selective submandibular neck dissection; RND: radical neck dissection; CI: confidence interval.