Review Article
Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2
Table 4
Different prevalence of RET germline mutations in hereditary MTC in different European countries.
| RET mutation | Italy () [14] | Germany () [15] |
Euromen () [16] |
| Cys634 | 86 (34.9%) | 57 (40%) | 98 (67.6%) | Val804 | 52 (21.1%) | 9 (6.4%) | 3 (2.1%) | Ser891 | 23 (9.3%) | 3 (2.2%) | 3 (2.1%) | Met918 | 20 (8.1%) | 21 (15%) | 4 (2.8%) | Cys618 | 15 (6.0%) | 7 (5%) | 10 (6.9%) | Glu768 | 9 (3.6%) | 2 (1.4%) | 1 (0.8%) | Cys620 | 9 (3.6%) | 10 (7%) | 10 (6.9%) | Leu790 | 8 (3.2%) | 17 (12%) | 7 (4.8%) | Cys609 | 6 (2.4%) | 1 (0.7%) | 1 (0.8%) | Cys630 | 4 (1.6%) | 1 (0.7%) | 1 (0.8%) | Cys611 | 1 (0.4%) | 2 (1.4%) | 4 (2.8%) | Tyr791 | 1 (0.4%) | 10 (7%) | 3 (2.1%) | Ala883 | 1 (0.4%) | 0 | 0 | Cys515 | 1 (0.4%) | 0 | 0 | Lys666 | 1 (0.4%) | 0 | 0 | Met848 | 1 (0.4%) | 0 | 0 | Ser904 | 1 (0.4%) | 0 | 0 | Thr338 | 1 (0.4%) | 0 | 0 | Asp631 | 0 | 1 (0.7%) | 0 | No mutations | 6 (2.4%) | 0 | 0 |
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