Modulation of Telomeres in Alternative Lengthening of Telomeres Type I Like Human Cells by the Expression of Werner Protein and Telomerase

Figure 6

Proposed role of WRN in transformation of ALT type I like telomere to ALT type II like telomere. In the WRN- and telomerase-deficient cell, ALT is activated. Selection of a cell with recombination in subtelomeric region gives rise to ALT type I like telomere. WRN transduction transforms the ALT I like telomere to ALT type II like telomere.