Modulation of Telomeres in Alternative Lengthening of Telomeres Type I Like Human Cells by the Expression of Werner Protein and Telomerase

Table 1

WRN and telomerase expression decreases sister telomere loss (STL) in AG11395. Fifteen metaphases per cell line were analyzed. P values indicated are from the Wilcoxon two-sided ranks test, comparing the WRN and telomerase-expressing clones to the pooled empty vector-infected controls.

Cell line	STL/cell	Significance
AG11395 EV1	11.4
AG11395 EV2	9.2
AG11395 EV3	10.6
AG11395 WRN1	7.1	𝑃<0.0005
AG11395 WRN2	6.9	𝑃<0.01
AG11395 WRN3	4.4	𝑃<0.0001
AG11395 hTERT	2.8	𝑃<0.00001