Dual Roles of METCAM in the Progression of Different Cancers

Figure 5

Effect of overexpression of moMETCAM on tumor formation of a mouse melanoma K1735 subline number 9 (K9) in immune competent syngeneic C3H mice. METCAM-K9H and METCAM-K9L were two transfected clones, which expressed a high and a low level of moMETCAM, respectively. Vector-K9 was one clone transfected with the empty vector, as a negative control. K9 was parental K1735 subline number 9 cells, also as a negative control. Rev-K9, in which the moMETCAM cDNA was inserted into the expression vector in antisense orientation, is also as a control clone. Vector-K9, K9, and Rev-K9 did not express any moMETCAM.