Dual Roles of METCAM in the Progression of Different Cancers

Table 1

The role of METCAM in the tumorigenesis and metastasis of various cancer cells.

Cancer cells	Tumorigenesis	Metastasis	References
Clinical prostate cancer and human prostate cancer cell lines	Increasing	Increasing (effect is in the early stage of initiation)	[7, 8, 12, 13, 35, 36]
Mouse prostate carcinomas in TRAMP mice	Increasing	Increasing	[41]
Clinical melanoma and human melanoma cell lines	No effect	Increasing (effect is in the late stages)	[3, 20]
Mouse melanoma cell line of K1735 subline number 3 and 10s	No effect or slight suppression	Increasing (effect is in the late stages)	[9, 21]
Mouse melanoma cell line K1735 subline number 9	Suppression	Suppression	[22, 23] and Wu et al. unpublished results
Angiosarcoma	Increasing	Not determined	[7, 37] and Wu et al. unpublished results
Human ovarian cancer cell lines BG-1 and SK-OV-3	Suppression	suppression	[33, 34]
Human osteosarcoma cell lines	Not determined	Increasing	[39]
Human breast cancer cell line MCF-7	Suppression	Not determined	[24]
Human breast cancer cell lines MCF-7 and SK-BR-3	Increasing	Not determined	[30, 31]
Haemangiomas	Suppression?	Not determined	[38]
Nasopharyngeal carcinoma	Suppression?	Not determined	[7, 11]