Tumor Angiogenesis as a Target for Dietary Cancer Prevention

Figure 1

The switch to the angiogenic phenotype occurs during multistage tumorigenesis. As malignancy develops, cells progress from a prevascular stage (normal to early hyperplasia) to a vascular stage (late hyperplasia to dysplasia to invasive carcinoma). Angiogenesis becomes clearly evident during dysplasia and is critical for further growth. Targeting tumor angiogenesis may be a novel strategy for preventing cancer. (Reprinted by permission from the Angiogenesis Foundation. Copyright 2011 by The Angiogenesis Foundation. All rights reserved).