Research Article

Human Papillomavirus Genotyping and E6/E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva

Table 4

Prevalence of HPV in intraepithelial neoplasia and carcinoma of the vulva, by study.

Histologic typeFirst
author
No. of
cases
HPV testHPV prevalence for any
and specific genotypes

VIN I
Smith (review)71PCR/hybrid capture assaysAny HPV, 77.5%
Most common types; 6 (23.8%), 16 (14.3%), 56 (1.7%)
De Vuyst (meta-analysis)90 PGMY reverse line blot/SPF 10 line probe assayAny HPV, 67.8%
Most common types; 6 (22.4%), 16 (9.8%), 11 (9.0%)
Garland (original article)31Reverse line blot assayAny HPV, 80.6%
Most common types; 6 or 11 (64.5%)

VIN II/III
Smith1340PCR/hybrid capture assaysAny HPV, 80.4%
Most common types; 16 (71.2%), 33 (7.7%)
De Vuyst1061PGMY reverse line blot/SPF 10 line probe assay, sequencing, southern hybridization, restriction fragment-length polymorphism analysisAny HPV, 85.3%
Most common types; 16 (71.9%), 33 (8.0%),18 (5.0%)
Garland31Reverse line blot assayAny HPV, 87.1%
Most common types; 16 (64.5%), 6, or HPV11 (29%)

Vulvar SCC
Smith1379PCR/hybrid capture assaysAny HPV, 40.1%
Most common types; 16 (29.3%), 18 (5.6%)
De Vuyst1873Reverse line blot hybridization, dot blot hybridization, Roche HPV linear arrayAny HPV, 40.4%
Most common HPV types; 16 (32.2%), 33 (4.5%), 18 (4.4%)