Copyright © 2012 Robert J. Griffin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

1. J. Fang, S. J. Chen, J. H. Tong, Z. G. Wang, G. Q. Chen, and Z. Chen, “Treatment of acute promyelocytic leukemia with ATRA and As2O3: a model of molecular target-based cancer therapy,” Cancer Biology & Therapy, vol. 1, no. 6, pp. 614–620, 2002. View at Scopus
2. X. Cai, Y. Yu, Y. Huang et al., “Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells,” Leukemia, vol. 17, no. 7, pp. 1333–1337, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
3. A. M. Evens, M. S. Tallman, and R. B. Gartenhaus, “The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future,” Leukemia Research, vol. 28, no. 9, pp. 891–900, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
4. W. H. Miller Jr., H. M. Schipper, J. S. Lee, J. Singer, and S. Waxman, “Mechanisms of action of arsenic trioxide,” Cancer Research, vol. 62, no. 14, pp. 3893–3903, 2002. View at Scopus
5. W. H. Miller Jr., “Molecular targets of arsenic trioxide in malignant cells,” Oncologist, vol. 7, supplement 1, pp. 14–19, 2002. View at Scopus
6. S. L. Soignet, P. Maslak, Z. G. Wang et al., “Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide,” The New England Journal of Medicine, vol. 339, no. 19, pp. 1341–1348, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
7. Y. S. Lew, S. L. Brown, R. J. Griffin, C. W. Song, and J. H. Kim, “Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown,” Cancer Research, vol. 59, no. 24, pp. 6033–6037, 1999. View at Scopus
8. R. J. Griffin, S. H. Lee, K. L. Rood et al., “Use of arsenic trioxide as an antivascular and thermosensitizing agent in solid tumors,” Neoplasia, vol. 2, no. 6, pp. 555–560, 2000. View at Scopus
9. R. J. Griffin, H. Monzen, B. W. Williams, H. Park, S. H. Lee, and C. W. Song, “Arsenic trioxide induces selective tumour vascular damage via oxidative stress and increases thermosensitivity of tumours,” International Journal of Hyperthermia, vol. 19, no. 6, pp. 575–589, 2003. View at Publisher · View at Google Scholar · View at Scopus
10. R. J. Griffin, B. W. Williams, H. J. Park, and C. W. Song, “Preferential action of arsenic trioxide in solid-tumor microenvironment enhances radiation therapy,” International Journal of Radiation Oncology Biology Physics, vol. 61, no. 5, pp. 1516–1522, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
11. J. H. Kim, Y. S. Lew, A. Kolozsvary, S. Ryu, and S. L. Brown, “Arsenic trioxide enhances radiation response of 9L glioma in the rat brain,” Radiation Research, vol. 160, no. 6, pp. 662–666, 2003. View at Publisher · View at Google Scholar · View at Scopus
12. Y. S. Lew, A. Kolozsvary, S. L. Brown, and J. H. Kim, “Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor,” Cancer Research, vol. 62, no. 15, pp. 4202–4205, 2002. View at Scopus
13. R. W. Ahn, F. Chen, H. Chen et al., “A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer,” Clinical Cancer Research, vol. 16, no. 14, pp. 3607–3617, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
14. H. Chen, R. Ahn, J. van den Bossche, D. H. Thompson, and T. V. O'Halloran, “Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide,” Molecular Cancer Therapeutics, vol. 8, no. 7, pp. 1955–1963, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
15. H. Monzen, R. J. Griffin, B. W. Williams, M. Amano, S. Ando, and T. Hasegawa, “Study of arsenic trioxide-induced vascular shutdown and enhancement with radiation in solid tumor,” Radiation Medicine, vol. 22, no. 4, pp. 205–211, 2004.
16. A. M. Westermann, E. L. Jones, B. C. Schem et al., “First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma,” Cancer, vol. 104, no. 4, pp. 763–770, 2005. View at Publisher · View at Google Scholar · View at PubMed
17. J. W. J. Bergs, N. A. P. Franken, J. Haveman, E. D. Geijsen, J. Crezee, and C. van Bree, “Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application,” International Journal of Hyperthermia, vol. 23, no. 4, pp. 329–341, 2007. View at Publisher · View at Google Scholar · View at PubMed
18. N. E. Hoffmann and J. C. Bischof, “Cryosurgery of normal and tumor tissue in the dorsal skin flap chamber: part I—thermal response,” Journal of Biomechanical Engineering, vol. 123, no. 4, pp. 301–309, 2001. View at Publisher · View at Google Scholar
19. V. S. Kalambur, H. Mahaseth, J. C. Bischof, et al., “Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy,” American Journal of Hematology, vol. 77, no. 2, pp. 117–125, 2004. View at Publisher · View at Google Scholar · View at PubMed
20. S. Bhowmick, N. E. Hoffmann, and J. C. Bischof, “Thermal therapy of prostate tumor tissue in the dorsal skin flap chamber,” Microvascular Research, vol. 64, no. 1, pp. 170–173, 2002. View at Publisher · View at Google Scholar · View at PubMed
21. R. J. Griffin, B. W. Williams, J. C. Bischof, M. Olin, G. L. Johnson, and B. W. Lee, “Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy,” Technology in Cancer Research and Treatment, vol. 6, no. 6, pp. 651–654, 2007.
22. J. Bernier, J. Denekamp, A. Rojas et al., “ARCON: accelerated radiotherapy with carbogen and nicotinamide in non small cell lung cancer: a phase I/II study by the EORTC,” Radiotherapy and Oncology, vol. 52, no. 2, pp. 149–156, 1999. View at Publisher · View at Google Scholar
23. W. C. Dewey, “Interaction of heat with radiation and chemotherapy,” Cancer Research, vol. 44, no. 10, pp. 4714s–4720s, 1984.
24. M. R. Horsman, D. J. Chaplin, and J. Overgaard, “Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells,” Cancer Research, vol. 50, no. 23, pp. 7430–7436, 1990.
25. M. Bischof, A. Abdollahi, P. Gong et al., “Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells,” International Journal of Radiation Oncology Biology Physics, vol. 60, no. 4, pp. 1220–1232, 2004. View at Publisher · View at Google Scholar · View at PubMed
26. T. S. Herman and B. A. Teicher, “Sequencing of trimodality therapy [cis-diamminedichloroplatinum(II)/hyperthermia/radiation] as determined by tumor growth delay and tumor cell survival in the FSaIIC fibrosarcoma,” Cancer Research, vol. 48, no. 10, pp. 2693–2697, 1988.
27. T. S. Herman, B. A. Teicher, and C. N. Coleman, “Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo,” Cancer Research, vol. 50, no. 16, pp. 5055–5059, 1990.
28. M. R. Horsman and R. Murata, “Combination of vascular targeting agents with thermal or radiation therapy,” International Journal of Radiation Oncology Biology Physics, vol. 54, no. 5, pp. 1518–1523, 2002. View at Publisher · View at Google Scholar
29. M. R. Horsman, R. Murata, and J. Overgaard, “Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation,” Acta Oncologica, vol. 40, no. 4, pp. 497–503, 2001. View at Publisher · View at Google Scholar
30. R. Murata and M. R. Horsman, “Tumour-specific enhancement of thermoradiotherapy at mild temperatures by the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid,” International Journal of Hyperthermia, vol. 20, no. 4, pp. 393–404, 2004. View at Publisher · View at Google Scholar · View at PubMed
31. T. S. Herman, M. S. Jochelson, B. A. Teicher et al., “A phase I-II trial of cisplatin, hyperthermia and radiation in patients with locally advanced malignancies,” International Journal of Radiation Oncology Biology Physics, vol. 17, no. 6, pp. 1273–1279, 1989.
32. T. S. Herman, B. A. Teicher, and S. A. Holden, “Trimodality therapy (drug/hyperthermia/radiation) with BCNU or mitomycin C,” International Journal of Radiation Oncology Biology Physics, vol. 18, no. 2, pp. 375–382, 1990.
33. P. E. Huber, M. Bischof, J. Jenne et al., “Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy,” Cancer Research, vol. 65, no. 9, pp. 3643–3655, 2005. View at Publisher · View at Google Scholar · View at PubMed
34. S. L. Hokland and M. R. Horsman, “The new vascular disrupting agent combretastatin-A1-disodium-phosphate (OXi4503) enhances tumour response to mild hyperthermia and thermoradiosensitization,” International Journal of Hyperthermia, vol. 23, no. 7, pp. 599–606, 2007. View at Publisher · View at Google Scholar · View at PubMed
35. R. Murata, J. Overgaard, and M. R. Horsman, “Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotheraphy,” International Journal of Radiation Oncology Biology Physics, vol. 51, no. 4, pp. 1018–1024, 2001. View at Publisher · View at Google Scholar
36. A. Hines-Peralta, V. Sukhatme, M. Regan, S. Signoretti, Z. J. Liu, and S. N. Goldberg, “Improved tumor destruction with arsenic trioxide and radiofrequency ablation in three animal models,” Radiology, vol. 240, no. 1, pp. 82–89, 2006. View at Publisher · View at Google Scholar · View at PubMed
37. P. J. Dilda, S. Decollogne, L. Weerakoon et al., “Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol,” Journal of Medicinal Chemistry, vol. 52, no. 20, pp. 6209–6216, 2009. View at Publisher · View at Google Scholar · View at PubMed
38. P. J. Dilda and P. J. Hogg, “Arsenical-based cancer drugs,” Cancer Treatment Reviews, vol. 33, no. 6, pp. 542–564, 2007. View at Publisher · View at Google Scholar · View at PubMed