Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation

Table 4

Rates of pseudoprogression reported in the literature in patients treated with radiotherapy and temozolomide.

Author	Year	Number of patients	Response criteria	Period of early-response assessment (months)	Number with ePD	psPD (% of ePD)	Overall rate of psPD
Chamberlain et al. [20]	2007	51	Not specified	6	26	7/15 (47%)	7/40 (18%)
Brandes et al. [13]	2008	103	Macdonald	1	50	32/50 (64%)	32/103 (31%)
Taal et al. [19]	2008	68	Macdonald	1	31	15/31 (48%)	15/68 (22%)
Chaskis et al. [21]	2009	54	Gd-MRI + clinical	6	25	3/12 (12%)	3/54 (6%)
Clarke and Chang [22]	2009	85	Macdonald	0.5–1	35	10/27 (37%)	10/77 (13%)
Fabi et al. [23]	2009	12	Macdonald	2	4	2/4 (50%)	2/12 (17%)
Peca et al. [24]	2009	50	Gd-MRI + MR Spectroscopy	6	15	4/15 (27%)	4/50 (8%)
Roldan et al. [8]	2009	43	Macdonald	1–1.5	25	10/20 (50%)	10/38 (26%)
Gerstner et al. [25]	2009	45	Macdonald	0.5–1	24	13/24 (54%)	13/45 (29%)
Sanghera et al. [5]	2010	104	RECIST	2	27	7/22 (32%)	7/99 (7%)
Tsien et al. [10]	2010	27	Macdonald	3	14	6/14 (43%)	6/27 (22%)
Yaman et al. [26]	2010	67	Gd-MRI + T2/FLAIR	6	17	4/17 (24%)	4/67 (6%)
Gunjur et al. [27]	2011	68	Macdonald	1	41	14/41 (34%)	14/68 (21%)
Kang et al. [12]	2011	35	Macdonald	1	18	8/18 (44%)	8/35 (23%)
Kong et al. [17]	2011	90	Macdonald + rCBV	2	59	26/59 (44%)	26/90 (29%)
Young et al. [28]	2011	321	Macdonald	0.5–1	205	30/93 (32%)	Not specified
Park et al. [29]	2011	48	Macdonald	1	25	11/25 (44%)	11/48 (23%)
Topkan et al. [30]	2012	63	Macdonald	6	28	12/28 (43%)	12/63 (19%)
Pouleau et al. [14]	2012	63	Gd-MRI + edema	2	33	7/33 (21%)	7/63 (11%)
Present study	2013	70	RANO; Macdonald	3	15; 42	2/15 (13%); 10/42 (24%)	2/70 (3%); 10/70 (14%)

ePD: early progressive disease; tPD: true progressive disease; psPD: pseudoprogression; Gd-MRI: gadolinium enhanced-MRI.