Progress in Using Circulating Tumor Cell Information to Improve Metastatic Breast Cancer Therapy

Table 1

Key concepts underlying the algorithm for management of metastatic breast cancer using circulating tumor cell information.

Key algorithm parameters
(1) Validation of the 5 CTC cutoffs for categorization survival prognosis at baseline and during treatment.
(2) Modulation of CTC prognostic value by type of therapy and disease subtype.
(3) Integration of CTC information with traditional imaging and serum biomarkers.