Review Article
Proteomics of Uveal Melanoma: A Minireview
Table 2
Protein change in the metastatic UM cell line.
| Category/name | Function | Change (-fold) |
| Cellular defense | | | HSP27 | Protein stabilisation | ++ | Apoptosis/degeneration | | | Cathepsin Z | Lysosomal proteolysis | ++ | Proliferation | | | Annexin | Growth factor | ++ | Migration | | | Cofilin | Actin turnover | +++ | Tropomodulin 3 | Actin turnover | ++++++ | CLIM1 | Actin kinase adaptor | ++++++ | Galectin | Cell to cell interaction | ++ | β-Hexosaminidase β-subunit |
Glycosidasis | ++++++ | Metabolism | | | Pyruvate kinase 3 | Glycolysis |
− | Enolase 1 | Glycolysis |
− | Nuclear transport | | | Ran-binding protein 1 | RanGAP activity | ++ | elF5A | Cofactor in nuclear export | ++++++ | Translation | | | CRHSP-24 | Translation regulating protein | ++++++ |
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Adapted from Zuidervaart et al. [37] (+) 0–1.5. (++) 1.5–5. (+++) 5–10. (++++) 10–50. (+++++) 50–100. (++++++) >100-fold increase. Minus depicts a decrease.
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