About this Journal Submit a Manuscript Table of Contents
Journal of Oncology
Volume 2013 (2013), Article ID 854121, 9 pages
http://dx.doi.org/10.1155/2013/854121
Review Article

Predictive Factors of Response in HER2-Positive Breast Cancer Treated by Neoadjuvant Therapy

1Medical Oncology, Centre Georges François Leclerc, 21000 Dijon, France
2Medical Oncology, Centre Jean Perrin, 63000 Clermont-Ferrand, France
3Oncology Department, CHU Treichville, BP V3 Abidjan, Cote D'Ivoire

Received 24 December 2012; Revised 22 March 2013; Accepted 6 April 2013

Academic Editor: Gunter Von Minckwitz

Copyright © 2013 S. Guiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Mauri, N. Pavlidis, and J. P. A. Ioannidis, “Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis,” Journal of the National Cancer Institute, vol. 97, no. 3, pp. 188–194, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Kaufmann, G. Von minckwitz, H. D. Bear et al., “Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006,” Annals of Oncology, vol. 18, no. 12, pp. 1927–1934, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Dawood, S. D. Merajver, P. Viens et al., “International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment,” Annals of Oncology, vol. 22, no. 3, pp. 515–523, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. U. Buzdar, N. K. Ibrahim, D. Francis et al., “Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer,” Journal of Clinical Oncology, vol. 23, no. 16, pp. 3676–3685, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. U. Buzdar, V. Valero, N. K. Ibrahim et al., “Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen,” Clinical Cancer Research, vol. 13, no. 1, pp. 228–233, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. H. R. Chang, J. Glaspy, M. A. Allison et al., “Differential response of triple-negative breast cancer to a docetaxel and carboplatin-based neoadjuvant treatment,” Cancer, vol. 116, no. 18, pp. 4227–4237, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Steger, R. Greil, R. Jakesz, et al., “Final Results of ABCSG-24, a Randomized Phase III Study Comparing Epirubicin, Docetaxel, and Capecitabine (EDC) to Epirubicin and Docetaxel (ED) as Neoadjuvant Treatment for Early Breast Cancer and Comparing ED/EDC + Trastuzumab (T) to ED/EDC as Neoadjuvant Treatment for Early HER-2 Positive Breast Cancer,” Cancer Research, vol. 69, supplement 24, 2009.
  8. L. Gianni, W. Eiermann, V. Semiglazov et al., “Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort,” The Lancet, vol. 375, no. 9712, pp. 377–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Y. Pierga, S. Delaloge, M. Espié et al., “A multicenter randomized phase II study of sequential epirubicin/ cyclophosphamide followed by docetaxel with or without celecoxib or trastuzumab according to HER2 status, as primary chemotherapy for localized invasive breast cancer patients,” Breast Cancer Research and Treatment, vol. 122, no. 2, pp. 429–437, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Untch, M. Rezai, S. Loibl et al., “Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study,” Journal of Clinical Oncology, vol. 28, no. 12, pp. 2024–2031, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Semiglazov, W. Eiermann, M. Zambetti, et al., “Surgery following neoadjuvant therapy in patients with HER2-positive locally advanced or inflammatory breast cancer participating in the NeOAdjuvant Herceptin (NOAH) study,” European Journal of Surgical Oncology, vol. 37, pp. 856–863, 2011.
  12. J. Baselga, I. Bradbury, H. Eidtmann, et al., “Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial,” The Lancet, vol. 379, pp. 633–640, 2012.
  13. M. Untch, S. Loibl, J. Bischoff, et al., “Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial,” The Lancet Oncology, vol. 13, pp. 135–144, 2012.
  14. V. Guarneri, A. Frassoldati, A. Bottini, et al., “Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB study,” Journal of Clinical Oncology, vol. 30, pp. 1989–1995, 2012.
  15. A. Robidoux, G. Tang, P. Rastogi, et al., “Evaluation of lapatinib as a component of neoadjuvant therapy for HER2+ operable breast cancer: NSABP protocol B-41,” Journal of Clinical Oncology, 2012.
  16. F. A. Holmes, Y. M. Nagarwala, V. A. Espina, et al., “Correlation of molecular effects and pathologic complete response to preoperative lapatinib and trastuzumab, separately and combined prior to neoadjuvant breast cancer chemotherapy,” Journal of Clinical Oncology, vol. 29, 2011.
  17. E. Alba, J. Albanell, J. de la Haba, et al., “Lapatinib vs trastuzumab in combination with standard EC-D chemotherapy in the neaodjuvant treatment of HER2+ patients. Results from the GEICAM 2006-14 phase II randomized trial,” Cancer Research, vol. 71, supplement 24, 2011.
  18. L. Gianni, T. Pienkowski, Y. H. Im, et al., “Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial,” The Lancet Oncology, vol. 13, pp. 25–32, 2012.
  19. V. Guarneri, A. Frassoldati, A. Bottini, et al., “Final results of a phase II randomized trial of neoadjuvant anthracycline-taxane chemotherapy plus lapatinib, trastuzumab, or both in HER2-positive breast cancer (CHER-LOB trial),” Journal of Clinical Oncology, vol. 29, 2011.
  20. W. Eiermann, J. Baselga, V. Semiglazov, et al., “Hormone-receptor status and likelihood of predicting pathological complete response (pCR) in the NOAH trial of neoadjuvant trastuzumab in patients (pts) with HER2-positive locally advanced breast cancer (LABC),” European Journal of Cancer, vol. 6, no. 7, p. 115, 2008. View at Publisher · View at Google Scholar
  21. N. L. Spector and K. L. Blackwell, “Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer,” Journal of Clinical Oncology, vol. 27, no. 34, pp. 5838–5847, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. P. R. Pohlmann, I. A. Mayer, and R. Mernaugh, “Resistance to trastuzumab in breast cancer,” Clinical Cancer Research, vol. 15, no. 24, pp. 7479–7491, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. C. E. Geyer, J. Forster, D. Lindquist et al., “Lapatinib plus capecitabine for HER2-positive advanced breast cancer,” The New England Journal of Medicine, vol. 355, no. 26, pp. 2733–2743, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Cameron, M. Casey, M. Press et al., “A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses,” Breast Cancer Research and Treatment, vol. 112, no. 3, pp. 533–543, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Xia, C. M. Gerard, L. Liu, N. M. Baudson, T. L. Ory, and N. L. Spector, “Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells,” Oncogene, vol. 24, no. 41, pp. 6213–6221, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. G. E. Konecny, M. D. Pegram, N. Venkatesan et al., “Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells,” Cancer Research, vol. 66, no. 3, pp. 1630–1639, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Scaltriti, C. Verma, M. Guzman et al., “Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity,” Oncogene, vol. 28, no. 6, pp. 803–814, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Maruyama, K. Mimura, S. Izawa, et al., “Lapatinib enhances herceptin-mediated antibody-dependent cellular cytotoxicity by up-regulation of cell surface HER2 expression,” Anticancer Research, vol. 31, pp. 2999–3005, 2011.
  29. K. L. Blackwell, H. J. Burstein, A. M. Storniolo et al., “Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer,” Journal of Clinical Oncology, vol. 28, no. 7, pp. 1124–1130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. K. L. Blackwell, H. J. Burstein, A. M. Storniolo, et al., “Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study,” Journal of Clinical Oncology, vol. 30, pp. 2585–2592, 2012.
  31. K. A. Gelmon, F. Boyle, B. Kaufman, et al., “Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919,” in ASCO Annual Meeting, 2012.
  32. http://www.gsk.com/media/pressreleases/2011/2011-pressrelease-614837.htm.
  33. R. Nahta, M. C. Hung, and F. J. Esteva, “The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells,” Cancer Research, vol. 64, no. 7, pp. 2343–2346, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Baselga, J. Cortes, S. B. Kim, et al., “Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer,” The New England Journal of Medicine, vol. 366, pp. 109–119, 2012.
  35. A. Valachis, D. Mauri, N. P. Polyzos, et al., “Trastuzumab combined to neoadjuvant chemotherapy in patients with HER2-positive breast cancer: a systematic review and meta-analysis,” Breast, vol. 20, pp. 485–490, 2011.
  36. A. Valachis, A. Nearchou, P. Lind, and D. Mauri, “Lapatinib, trastuzumab or the combination added to preoperative chemotherapy for breast cancer: a meta-analysis of randomized evidence,” Breast Cancer Research and Treatment, vol. 135, pp. 655–662, 2012.
  37. H. M. Kuerer, L. A. Newman, T. L. Smith et al., “Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy,” Journal of Clinical Oncology, vol. 17, no. 2, pp. 460–469, 1999. View at Scopus
  38. A. E. Ring, I. E. Smith, S. Ashley, L. G. Fulford, and S. R. Lakhani, “Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer,” British Journal of Cancer, vol. 91, no. 12, pp. 2012–2017, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Kaufmann, G. N. Hortobagyi, A. Goldhirsch et al., “Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update,” Journal of Clinical Oncology, vol. 24, no. 12, pp. 1940–1949, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. V. Guarneri, K. Broglio, S. W. Kau et al., “Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors,” Journal of Clinical Oncology, vol. 24, no. 7, pp. 1037–1044, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. C. Wang, G. Morrison, R. Gillihan, et al., “Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-positive breast cancers—role of estrogen receptor and HER2 reactivation,” Breast Cancer Research, vol. 13, p. R121, 2011.
  42. B. Dave, I. Migliaccio, M. C. Gutierrez et al., “Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2 - Overexpressing locally advanced breast cancers,” Journal of Clinical Oncology, vol. 29, no. 2, pp. 166–173, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Berns, H. M. Horlings, B. T. Hennessy et al., “A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer,” Cancer Cell, vol. 12, no. 4, pp. 395–402, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. Nagata, K. H. Lan, X. Zhou et al., “PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients,” Cancer Cell, vol. 6, no. 2, pp. 117–127, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Barbareschi, L. V. Cuorvo, S. Girlando, et al., “PI3KCA mutations and/or PTEN loss in Her2-positive breast carcinomas treated with trastuzumab are not related to resistance to anti-Her2 therapy,” Virchows Archiv, vol. 461, pp. 129–139, 2012.
  46. L. Wang, Q. Zhang, J. Zhang et al., “PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib,” BMC Cancer, vol. 11, article 248, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. M. A. Molina, R. Sáez, E. E. Ramsey et al., “NH2-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer,” Clinical Cancer Research, vol. 8, no. 2, pp. 347–353, 2002. View at Scopus
  48. M. Scaltriti, S. Chandarlapaty, L. Prudkin et al., “Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor,” Clinical Cancer Research, vol. 16, no. 9, pp. 2688–2695, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Scaltriti, F. Rojo, A. Ocaña et al., “Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer,” Journal of the National Cancer Institute, vol. 99, no. 8, pp. 628–638, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. S. Loibl, J. Bruey, G. Von Minckwitz, et al., “Validation of p95 as a predictive marker for trastuzumab-based therapy in primary HER2-positive breast cancer: a translational investigation from the neoadjuvant GeparQuattro study,” in ASCO Annual Meeting, 2011.
  51. M. A. Molina, J. Codony-Servat, J. Albanell, F. Rojo, J. Arribas, and J. Baselga, “Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells,” Cancer Research, vol. 61, no. 12, pp. 4744–4749, 2001. View at Scopus
  52. I. Witzel, S. Loibl, G. Von Minckwitz et al., “Monitoring serum HER2 levels during neoadjuvant trastuzumab treatment within the GeparQuattro trial,” Breast Cancer Research and Treatment, vol. 123, no. 2, pp. 437–445, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. I. Witzel, S. Loibl, G. von Minckwitz, et al., “Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab—a translational project in the neoadjuvant GeparQuinto trial,” British Journal of Cancer, vol. 107, pp. 956–960, 2012.
  54. C. Mazouni, A. Hall, K. Broglio et al., “Kinetics of serum HER-2/neu changes in patients with HER-2-positive primary breast cancer after initiation of primary chemotherapy,” Cancer, vol. 109, no. 3, pp. 496–501, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. E. J. Jung, L. Santarpia, J. Kim, et al., “Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients,” Cancer, vol. 118, pp. 2603–2614, 2012.
  56. K. Tamura, C. Shimizu, T. Hojo et al., “FcγR2A and 3A polymorphisms predict clinical outcome of trastuzumab in both neoadjuvant and metastatic settings in patients with HER2-positive breast cancer,” Annals of Oncology, vol. 22, no. 6, pp. 1302–1307, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. F. J. Esteva, J. Wang, F. Lin et al., “CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer,” Breast Cancer Research, vol. 9, no. 6, p. R87, 2007. View at Scopus
  58. L. Gianni, W. Eiermann, L. Pusztai, et al., “Biomarkers as potential predictors of pathologic complete response (pCR) in the NOAH trial of neoadjuvant trastuzumab in patients (pts) with HER2-positive locally advanced breast cancer (LABC),” Journal of Clinical Oncology, vol. 26, no. 15S, p. 8s, 2008.
  59. A. Berriolo-Riedinger, C. Touzery, J. M. Riedinger et al., “[18F]FDG-PET predicts complete pathological response of breast cancer to neoadjuvant chemotherapy,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 12, pp. 1915–1924, 2007. View at Publisher · View at Google Scholar · View at Scopus
  60. C. Rousseau, A. Devillers, C. Sagan et al., “Monitoring of early response to neoadjuvant chemotherapy in stage II and III breast cancer by [18F]fluorodeoxyglucose positron emission tomography,” Journal of Clinical Oncology, vol. 24, no. 34, pp. 5366–5372, 2006. View at Publisher · View at Google Scholar · View at Scopus
  61. J. Schwarz-Dose, M. Untch, R. Tiling et al., “Monitoring primary systemic therapy of large and locally advanced breast cancer by using sequential positron emission tomography imaging with [18F]fluorodeoxyglucose,” Journal of Clinical Oncology, vol. 27, no. 4, pp. 535–541, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. X. Cheng, Y. Li, B. Liu, et al., “18F-FDG PET/CT and PET for evaluation of pathological response to neoadjuvant chemotherapy in breast cancer: a meta-analysis,” Acta Radiologica, vol. 53, pp. 615–627, 2012.
  63. O. Humbert, A. Berriolo-Riedinger, J. M. Riedinger, et al., “Changes in 18F-FDG tumor metabolism after a first course of neoadjuvant chemotherapy in breast cancer: influence of tumor subtypes,” Annals of Oncology, vol. 23, pp. 2572–2577, 2012.
  64. A. Cochet, K. Kerrou, J. M. Nabholtz, et al., “An open-label randomized, multicenter, phase II study on neoadjuvant treatment with trastuzumab plus docetaxel versus trastuzumab plus docetaxel plus bevacizumab according to positron emission tomography (PET) value modification in aptients with early stage HER2-positive breast cancer (AVATAXHER),” in ASCO Annual Meeting, 2012.