Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane

Figure 1

Effect of EGCG and SFN on cisplatin-sensitive (A2780) and cisplatin-resistant (A2780/CP20) ovarian cancer cells. (a) and (b) EGCG and SFN dose-dependently inhibit viability of cisplatin-sensitive (A2780) and cisplatin-resistant ovarian cancer cells (A2780/CP20). EGCG enhances the SFN-mediated growth inhibiting effect in both cell lines. Cells were treated with 2.5, 5, 10, 20, and 40 μM of EGCG, 2.5, 5, 10, 15, and 20 μM of SFN or combination of EGCG and SFN (the first number represents the concentration of EGCG used, while the second number represents the concentration of SFN used). (c) and (d) EGCG and SFN time-dependently inhibit proliferation of cisplatin-sensitive (A2780) and cisplatin-resistant (A2780/CP20) ovarian cancer cells. ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001.

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