Development of a Score Predicting Survival after Palliative Reirradiation
Table 1
Patient characteristics.
Characteristic
No.
%
Entire cohort
87
Gender
Male
65
75
Female
22
25
Family status1
Single
20
23
Married
55
63
Partner
5
6
Missing information
7
8
Karnofsky performance status
90–100
31
36
70–80
30
34
≤60
26
30
Primary tumor site
Prostate
25
29
Breast
9
10
Lung (non-small cell)
10
11
Colorectal
8
9
Bladder
5
6
Kidney
6
7
Skin (malignant melanoma)
3
3
Other
21
24
Dose/fractionation (intention-to-treat)
10 fractions of 3 Gy
24
28
Single fraction of 8 Gy
19
22
5 fractions of 4 Gy
15
17
12–15 fractions of 2.5 Gy
4
5
Other
25
29
Reirradiation target types
Bone metastases
69
79
Brain metastases
5
6
Lung metastases or primary tumor
6
7
Other
7
8
Known brain metastases
No
80
92
One or more
7
8
Known liver metastases
No
68
78
One or more
19
22
Known lung metastases
No
65
75
One or more
22
25
Known adrenal gland metastases
No
76
87
One or more
11
13
Known bone metastases
No
14
16
One or more
73
84
Metastatic spinal cord compression
No
80
92
Yes (radiologic or symptomatic)
7
8
Pleural effusion
No
81
93
Yes (radiologic or symptomatic)
6
7
Number of metastatic sites
0
10
11
1 (e.g., lungs only)
37
43
2 (e.g., lungs and brain)
27
31
3
11
13
4
2
2
Progressive disease outside RT target volume1
No
27
31
Yes
55
63
Missing information
5
6
Systemic cancer treatment1
No
23
26
Within 4 weeks before RT
21
24
Within 3 months before RT
14
16
Earlier
17
20
Missing information
12
14
Use of opioid analgetics at start of RT1
No
21
24
Yes
54
62
Missing information
12
14
Use of steroids at start of RT1
No
32
37
Yes
38
44
Missing information
17
20
Serum hemoglobin1
Low2
66
76
Normal
16
18
Missing information
5
6
Serum albumin1
Low2
17
20
Normal
42
48
Missing information
28
32
Serum lactate dehydrogenase1
Normal2
14
16
Elevated
35
40
Missing information
38
44
Serum alkaline phosphatase1
Normal2
25
29
Elevated
29
33
Missing information
33
38
Serum creatinine1
Low2
13
15
Normal
48
55
Elevated
15
17
Missing information
11
13
Serum C-reactive protein1
Normal2
20
23
Elevated but less than 30 mg/L
27
31
Elevated 30–60 mg/L
14
16
Elevated >60 mg/L
17
20
Missing information
9
10
Thrombocyte count1
Low2
11
13
Normal
45
52
High
19
22
Missing information
12
14
Charlson comorbidity index1
0
7
8
1-2
44
51
3 or more
28
32
Missing information
8
9
Smoking status1
Current smoker
34
39
No
34
39
Missing information
19
22
RT: radiotherapy.
1Missing information in some cases.
2Hematology and blood chemistry results refer to institutional limits of normal; only test results obtained within one week before RT were considered.