Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene

Figure 1

Schematic of glycolysis in a mammalian cell showing a branch point wherein glycolytic intermediate 3-phosphoglycerate can be channeled into a serine biosynthetic pathway via the activity of putative metabolic oncogene phosphoglycerate dehydrogenase (red), adapted from Hamanaka and Chandel [15].