The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="center" colspan="2">PICO statement</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Patient/problem (P)</td><td align="center">Postmenopausal breast cancer patients/low BMD <svg height="11.6125" id="M5" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.45 11.6125" width="11.45" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.55)"><path d="M649 676l-22 -187l-33 -2q3 56 -12 94q-8 20 -31.5 26.5t-86.5 6.5h-74l-90 -491q-4 -23 -6 -36.5t1 -25t7 -16.5t18 -9t27 -5t41 -3l-6 -28h-286l4 28q68 5 84 18.5t28 76.5l94 491h-55q-74 0 -100.5 -6t-41.5 -23q-24 -29 -54 -98l-32 1q32 98 53 188h22q7 -18 15 -22
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</svg> score, musculoskeletal ADRs</td></tr><tr><td align="left">Intervention (I)</td><td align="center">Third-generation BPs and AIs</td></tr><tr><td align="left">Comparison (if any) (C)</td><td align="center">Immediate and delayed therapy/placebo</td></tr><tr><td align="left">Outcome (O)</td><td align="center">Increase in BMD <svg height="11.6125" id="M6" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.45 11.6125" width="11.45" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.55)"><path d="M649 676l-22 -187l-33 -2q3 56 -12 94q-8 20 -31.5 26.5t-86.5 6.5h-74l-90 -491q-4 -23 -6 -36.5t1 -25t7 -16.5t18 -9t27 -5t41 -3l-6 -28h-286l4 28q68 5 84 18.5t28 76.5l94 491h-55q-74 0 -100.5 -6t-41.5 -23q-24 -29 -54 -98l-32 1q32 98 53 188h22q7 -18 15 -22
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</svg> score</td></tr><tr><td align="left">Type of question</td><td align="center">Therapy</td></tr><tr><td align="left">Type of study</td><td align="center">Randomised control trials</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Journal of Oncology

tab1

Table 1

Table 1: The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis 

Table 1 | The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis 