Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases

Table 2

Clinical characteristics in metastatic disease.

	Year	Age	Sex	Histology	Mets. site	Stones	Chemotherapy	Radiation	Survival	Ref.
1	1981	58	F	SCC	Hilar LN	Y	None	N	4	[1]
2	1984	79	F	SCC	Regional LN, liver	Y	None	N	4	[2]
3	1984	55	F	SCC	LN, liver	Y	Adr., Vinc., Cyclophos., Nitro.	N	11	[2]
4	1984	N/A	F	SCC	Regional LN, liver	Y	None	N	4	[2]
5	1984	52	F	SCC	Liver	N	Adr., Vinc., Cyclophos., Nitro.	N	13	[2]
6	1988	44	M	SCC	LN, liver, omentum, and colon	N	None	N	>2	[17]
7	1988	75	F	SCC	Liver	N	None	N	9	[17]
8	1988	56	F	SCC	Liver, abdominal wall	N	None	N	2	[17]
9	1991	71	F	SCC, adenocarcinoma	Liver, hilar LN, and peritoneum	N	None	N	4	[26]
10	1992	62	F	SCC	Liver, duodenum	N	None	N	5	[27]
11	1992	60	M	SCC	LN, liver	Y	Cis., Etop.	N	>18	[28]
12	1993	68	F	SCC	LN	N/A	None	N	2	[19]
13	1993	64	F	SCC	LN	N/A	None	N	6	[19]
14	1993	43	F	SCC	LN, liver	N/A	None	N	10	[19]
15	1993	57	M	SCC	Liver	N/A	None	N	N/A	[19]
16	1996	37	F	SCC	LN, liver, and omentum	N/A	Cis., Etop.	N	13	[29]
17	1996	82	M	SCC	LN, liver	N/A	None	N	1	[29]
18	1998	72	M	SCC	Liver	N/A	Platinum, Etop.	N	>16	[11]
19	1998	76	F	SCC, intestinal metaplastic epithelium	LN, liver	N/A	None	N/A	N/A	[30]
20	1999	69	F	SCC, poorly diff. adenocarcinoma	LN, liver, small bowel, and omentum	N	Cis., Etop.	N	44	[31]
21	1999	69	M	SCC	RP LN	Y	Strep., 5-FU	Y	21	[31]
22	1999	71	F	SCC, poorly diff. adenocarcinoma	RP LN, liver, and peritoneum	Y	5-FU	Y	13	[31]
23	2001	62	M	SCC	LN, liver	Y	Cis., Etop.	N	17	[3]
24	2001	56	M	SCC	Liver	Y	5-FU, Cis., Doce., Carbo.	N	13	[32]
25	2001	70	F	SCC	Liver	N/A	None	N	1	[33]
26	2005	48	M	SCC	LN, liver	N/A	Gem., Cis.	N	7	[34]
27	2005	51	M	SCC	LN, liver	N/A	Gem., Cis.	N	5	[34]
28	2005	47	F	SCC	Liver	N/A	Pac, Ifos., Cis.	N	>12	[35]
29	2005	49	F	SCC	Liver	N/A	Pac, Ifos., Cis.	N	>10	[35]
30	2006	77	F	SCC	LN, liver	N/A	Chemo N/A	N	N/A	[36]
31	2008	76	F	SCC	LN, liver	N/A	Cis., Etop.	N	>10	[37]
32	2011	54	F	SCC	LN, liver	N	Carbo.	N	3	[7]
33	2009	32	F	SCC	LN, liver	N/A	Cis., Etop.	N	>9	[15]
34	2015	89	M	SCC	LN, liver, and lung	N	None	N	3

SCC = small cell carcinoma; LN = distant lymph nodes; RP = retroperitoneal; Adr. = adriamycin; Vinc. = vincristine; Cyclophos. = cyclophosphamide; Nitro. = nitrosourea; Cis. = cisplatin; Etop. = etoposide; Dox. = doxorubicin; Mito. = mitomycin; Doce. = Docetaxel; Carbo. = carboplatin; chemo N/A = chemotherapy (agents not identified); Pac = paclitaxel.
= present case.