TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC

Table 1

Predictors of localized 237 RCC cases postoperative specific mortality.

Categories	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
pT1a versus pT1b; 94 versus 74	2.38 (1.02–5.55)	0.046	1.35 (0.96–1.88)	0.086
pT1a versus pT2a; 94 versus 43	1.40 (0.49–4.0)	0.53	1.07 (0.93–1.42)	0.74
pT1a versus pT2b; 94 versus 26	4.0 (1.51–1.020)	0.005	1.09 (0.66–1.85)	0.71
Clear versus nonclear; 190 versus 47	2.05 (1.00–4.019)	0.048	1.12 (0.77–1.65)	0.53
Nuclear Grades 1 and 2 versus 3 and 4; 190 versus 47	1.79 (1.76–6.84)	<0.001	1.50 (1.03–2.22)	0.037
MVI (−) versus (+); 154 versus 83	1.95 (0.92–2.94)	0.025	1.04 (0.33–1.21)	0.94
MMP-2 weak versus strong; 82 versus 155	3.69 (1.43–9.52)	0.0069	1.26 (0.30–5.23)	0.74
MMP-9 weak versus strong; 181 versus 56	4.29 (2.17–8.16)	<0.0001	2.88 (0.92–2.94)	0.75
TIMP-1 weak versus strong; 42 versus 195	2.52 (0.77–8.26)	0.12	1.014 (0.709–1.45)	0.34
TIMP-2 weak versus strong; 201 versus 36	2.07 (0.99–4.31)	0.052	1.12 (1.36–3.29)	0.020
MT-MMP-1 weak versus strong; 194 versus 43	3.44 (1.73–6.84)	0.005	1.84 (1.21–2.82)	0.045