TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC

Table 2

Correlation between pT category and pathological features with localized 237 RCC cases.

	pT1a versus pT1b	pT1a and pT1b versus pT2a	pT1a, pT1b, and pT2a versus pT2b
	Odds ratio (95% CI) value	Odds ratio (95% CI) value	Odds ratio (95% CI) value
	94 versus 74	168 versus 43	211 versus 26
	Cases of each category	Cases of each category	Cases of each category
Cell type	2.43 (0.85–6.89) 0.09	2.28 (0.76–6.82) 0.13	2.32 (0.84–6.36) 0.10
Clear versus others	139 versus 29	175 versus 36	190 versus 47
Nuclear grade	1.79 (0.57–5.56) 0.31	5.15 (1.87–14.2) 0.0015	3.39 (1.20–9.58) 0.020
Low versus high	147 versus 21	176 versus 35	190 versus 47
MVI	1.95 (0.92–4.16) 0.08	3.08 (1.47–6.48) 0.002	2.91 (1.19–7.11) 0.018
(−) versus (+)	123 versus 45	144 versus 67	154 versus 83
MMP-2	1.14 (0.55–2.36) 0.71	2.13 (0.90–5.0) 0.84	1.24 (0.41–3.70) 0.70
Weak versus strong	60 versus 108	76 versus 135	82 versus 156
MMP-9	1.79 (0.65–4.90) 0.205	1.47 (0.55–3.94) 0.43	1.31 (0.40–4.21) 0.64
Weak versus strong	134 versus 34	163 versus 48	181 versus 56
TIMP-1	3.30 (1.32–8.26) 0.010	1.18 (0.43–3.26) 0.74	1.59 (0.49–5.10) 0.42
Weak versus strong	31 versus 137	37 versus 174	42 versus 195
TIMP-2	1.41 (0.48–4.13) 0.53	2.14 (0.65–6.99) 0.84	3.03 (0.71–12.98) 0.13
Weak versus strong	142 versus 26	178 versus 33	201 versus 36
MT-MMP-1	1.93 (0.65–5.71) 0.096	2.28 (0.76–3.50) 0.15	1.98 (0.60–6.54) 0.26
Weak versus strong	144 versus 26	176 versus 35	194 versus 43

MVI: microvascular invasion.