Variability of Oxaliplatin-Induced Neuropathic Pain Symptoms in Each Cycle and Its Implications on the Management of Colorectal Cancer Patients: A Retrospective Study in South Western Sydney Local Health District Hospitals, Sydney, Australia
Table 1
Scoring criteria used for chemotherapy-induced adverse events.
CTCAE grading
0
1
2
3
4
Neurotoxicity
Peripheral
None
Loss of tendon reflexes or paraesthesia (including tingling) but not interfering with function
Sensory alteration or paraesthesia (including tingling) interfering with function but not interfering with daily living
Interfering with daily living
Disabling
Cold-induced perioral paraesthesia
None
Mild
Moderate
Severe
Disabling
Cold-induced pharyngolaryngeal dysesthesia
None
Mild
Moderate
Severe
Disabling
Cold-induced paraesthesia in the upper extremities
None
Mild
Moderate
Severe
Disabling
Cold-induced paraesthesia in the lower extremities
None
Mild
Moderate
Severe
Disabling
GI toxicity (hepatic)
Diarrhoea
None
Transient <2 days
Tolerable but >2 days
Intolerable requiring therapy
Haemorrhagic dehydration
Nausea/vomiting
None
Nausea
Transient vomiting
Vomiting requiring therapy
Intractable vomiting
Constipation
None
Mild
Moderate
Abdominal distention
Distention and vomiting
Oral (stomatitis)
None
Soreness/erythema
Erythema, ulcers, can eat solids
Ulcers, requires liquid diet only
Alimentation not possible
Bilirubin
≤1.25 × N
1.26–2.5 × N
2.6–5 × N
5.1–10 × N
>10 × N
SGOT/SGPT
≤1.25 × N
1.26–2.5 × N
2.6–5 × N
5.1–10 × N
>I0 × N
Alkaline phosphatase
≤1.25 × N
1.26–2.5 × N
2.6–5 × N
5.1–10 × N
>10 × N
Haematological toxicity
Haemoglobin (g/100 ml)
≥11.0
9.5–10.9
8.0–9.4
6.5–7.9
<6.5
Leukocytes (1000/cmm)
≥4.0
3.0–3.9
2.0–2.9
1.0–1.9
<1.0
Granulocytes (1000/cmm)
≥2.0
1.5–1.9
1.0–1.4
0.5–0.9
<0.5
Platelets (I000/cmm)
≥100
75–99
50–74
25–49
<25
Haemorrhage
None
Petechiae
Mild blood loss
Gross blood loss
Debilitating blood loss
Renal toxicity
BUN or blood urea
≤1.25 × N
1.26–2.5 × N
2.6–5 × N
5–10 × N
>I0 × N
Creatinine
≤1.25 × N
1.26–2.5 × N
2.6–5 x N
5–10 × N
>I0 × N
Proteinuria
None
I+, <0.3 g/100 ml
2-3+, 0.3–1.0 g/100 ml
4+, >1.0 g/100 ml
Nephrotic syndrome
Heamaturia
None
Microscopic
Gross
Gross + clots
Obstructive uropathy
N = upper limit of the normal value; BUN = blood urea nitrogen; SGOT = serum glutamic-oxaloacetic transaminase; SGPT = serum glutamic-pyruvic transaminase; CTCAE = Common Terminology Criteria for Adverse Events.