Variability of Oxaliplatin-Induced Neuropathic Pain Symptoms in Each Cycle and Its Implications on the Management of Colorectal Cancer Patients: A Retrospective Study in South Western Sydney Local Health District Hospitals, Sydney, Australia

Table 1

Scoring criteria used for chemotherapy-induced adverse events.

CTCAE grading		0	1	2	3	4
Neurotoxicity	Peripheral	None	Loss of tendon reflexes or paraesthesia (including tingling) but not interfering with function	Sensory alteration or paraesthesia (including tingling) interfering with function but not interfering with daily living	Interfering with daily living	Disabling
	Cold-induced perioral paraesthesia	None	Mild	Moderate	Severe	Disabling
	Cold-induced pharyngolaryngeal dysesthesia	None	Mild	Moderate	Severe	Disabling
	Cold-induced paraesthesia in the upper extremities	None	Mild	Moderate	Severe	Disabling
	Cold-induced paraesthesia in the lower extremities	None	Mild	Moderate	Severe	Disabling
GI toxicity (hepatic)	Diarrhoea	None	Transient <2 days	Tolerable but >2 days	Intolerable requiring therapy	Haemorrhagic dehydration
	Nausea/vomiting	None	Nausea	Transient vomiting	Vomiting requiring therapy	Intractable vomiting
	Constipation	None	Mild	Moderate	Abdominal distention	Distention and vomiting
	Oral (stomatitis)	None	Soreness/erythema	Erythema, ulcers, can eat solids	Ulcers, requires liquid diet only	Alimentation not possible
	Bilirubin	≤1.25 × N	1.26–2.5 × N	2.6–5 × N	5.1–10 × N	>10 × N
	SGOT/SGPT	≤1.25 × N	1.26–2.5 × N	2.6–5 × N	5.1–10 × N	>I0 × N
	Alkaline phosphatase	≤1.25 × N	1.26–2.5 × N	2.6–5 × N	5.1–10 × N	>10 × N
Haematological toxicity	Haemoglobin (g/100 ml)	≥11.0	9.5–10.9	8.0–9.4	6.5–7.9	<6.5
	Leukocytes (1000/cmm)	≥4.0	3.0–3.9	2.0–2.9	1.0–1.9	<1.0
	Granulocytes (1000/cmm)	≥2.0	1.5–1.9	1.0–1.4	0.5–0.9	<0.5
	Platelets (I000/cmm)	≥100	75–99	50–74	25–49	<25
	Haemorrhage	None	Petechiae	Mild blood loss	Gross blood loss	Debilitating blood loss
Renal toxicity	BUN or blood urea	≤1.25 × N	1.26–2.5 × N	2.6–5 × N	5–10 × N	>I0 × N
	Creatinine	≤1.25 × N	1.26–2.5 × N	2.6–5 x N	5–10 × N	>I0 × N
	Proteinuria	None	I+, <0.3 g/100 ml	2-3+, 0.3–1.0 g/100 ml	4+, >1.0 g/100 ml	Nephrotic syndrome
	Heamaturia	None	Microscopic	Gross	Gross + clots	Obstructive uropathy

N = upper limit of the normal value; BUN = blood urea nitrogen; SGOT = serum glutamic-oxaloacetic transaminase; SGPT = serum glutamic-pyruvic transaminase; CTCAE = Common Terminology Criteria for Adverse Events.