Table 3: Comparative efficacy of pharmacotherapy from recent meta-analyses of long-term studies in adults (12 months or more).

DrugNo. of studiesTotal subjectsMean weight difference (kg) (95% CI)Reference

Rimonabant4Placebo: ~1600 Rimonabant: ~25004.7 (4.1, 5.3)[9, 57, 58]
Orlistat14Placebo: 4509
Orlistat: 4948
2.9 (2.5, 3.2)[57, 58]
Sibutramine7Placebo: 699 Sibutramine: 8374.2 (3.6, 4.8)[57, 58]
Sibutramine Orlistat5Sibutramine: 229 Orlistat: 2493.4 (2.3, 4.6)[59]
5Bupropion: 618
Placebo: 344
2.8 kg (1.1 to 4.5 kg)[56]

CI: confidence interval; 6 to 12 month studies.
Note: another meta-analysis of 5 studies with rimonabant compared to placebo, did not provide mean weight difference in kg, however the odds ratio was 1.07 (95% CI 0.9, 1.3) [60].