Table 6: Recent randomised controlled trials of weight loss therapies with 2-years followup.

DrugNo subjectsOutcomesSerious adverse eventsReference
Absolute weight loss (kg) (95% CI)≥5% weight loss≥10% weight lossChange in WC (cm)

LorcaserinP-684 50.3%7.7% NS[120]
L-564 67.9%22.6%

TaranabantP-2441.4 (0.3, 2.5)30.3%13.4−2.7 (1.5, 3.8)NS[23]
TB 2 mg-2646.4 (5.3, 7.4),
59.6, 33, 1−6.3 (5.2, 7.4)
TB 4 mg-2607.6 (6.5, 8.7),
64.8, 37.9, −7.0 (5.9, 8.1),

Absolute weight loss = weight loss from baseline; WC: waist circumference, NR: not recorded, TB: taranabant, NS: not significant; P: placebo; L: lorcaserin.