Research Article
Mendelian Randomisation Study of Childhood BMI and Early Menarche
Table 2
Associations between individual BMI-increasing variants and BMI at age 20 years in 8,156 EPIC-Norfolk women.
| | Nearby gene | SNP | Chromosome | Position | B* (kg/m2/allele) | Lower CI | Upper CI |
| | SEC16B | rs10913469 |
1
|
176180142
|
0.28
|
0.17
|
0.38
| | TMEM18 | rs6548238 |
2
|
624905
|
0.21
|
0.10
|
0.32
| | FTO | rs1121980 |
16
|
52366748
|
0.20
|
0.11
|
0.29
| | FAIM2 | rs7132908 |
12
|
48549415
|
0.15
|
0.06
|
0.23
| | BDNF | rs925946 |
11
|
27623778
|
0.13
|
0.03
|
0.22
| | MC4R | rs17782313 |
18
|
56002077
|
0.13
|
0.03
|
0.23
| | GNPDA2 | rs10938397 |
4
|
45023455
|
0.10
|
0.01
|
0.19
| | SH2B1 | rs7498665 |
16
|
28790742
|
0.09
|
0.00
|
0.18
| | NEGR1 | rs2568958 |
1
|
72477137
|
0.08
|
−0.01
|
0.16
| | ETV5 | rs7647305 |
3
|
187316992
|
0.08
|
−0.03
|
0.18
| | MTCH2 | rs10838738 |
11
|
47619625
|
0.08
|
−0.02
|
0.17
| | KCTD15 | rs368794 |
19
|
39012292
|
0.06
|
−0.03
|
0.15
|
|
|
*B: regression coefficient from additive genetic models for the previously reported BMI-increasing allele.
|
