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Journal of Obesity
Volume 2011 (2011), Article ID 252817, 19 pages
http://dx.doi.org/10.1155/2011/252817
Review Article

AMPK as Target for Intervention in Childhood and Adolescent Obesity

1Endocrine and Metabolic Diseases Research Center, University of Zulia, School of Medicine, Final Avenida 20, Edificio Multidisciplinario, primer piso, Maracaibo 4004, Venezuela
2Clinical Pharmacologic Unit, Vargas Medical School, Central University of Venezuela, Caracas 1010, Venezuela

Received 18 May 2010; Revised 25 July 2010; Accepted 15 October 2010

Academic Editor: S. B. Heymsfield

Copyright © 2011 Joselyn Rojas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. Ulijaszek, “Seven models of population obesity,” Angiology, vol. 59, no. 2, pp. 34s–38s, 2008. View at Scopus
  2. I. Ioannidis, “The road from obesity to type 2 diabetes,” Angiology, vol. 59, no. 2, pp. 39s–43s, 2008. View at Scopus
  3. World Health Organization (WHO), “Obesity and overweight,” http://www.who.int/mediacentre/factsheets/fs311/en/index.html.
  4. C. L. Ogden, K. M. Flegal, M. D. Carroll, and C. L. Johnson, “Prevalence and trends in overweight among US children and adolescents, 1999-2000,” Journal of the American Medical Association, vol. 288, no. 14, pp. 1728–1732, 2002. View at Scopus
  5. J. P. Sekhobo, L. S. Edmunds, D. K. Reynolds, K. Dalenius, and A. Sharma, “Trends in prevalence of obesity and overweight among children enrolled in the New York State WIC Program, 2002–2007,” Public Health Reports, vol. 125, no. 2, pp. 218–224, 2010.
  6. G. S. Berenson, S. R. Srinivasan, W. Bao, W. P. Newman III, R. E. Tracy, and W. A. Wattigney, “Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults,” New England Journal of Medicine, vol. 338, no. 23, pp. 1650–1656, 1998. View at Publisher · View at Google Scholar
  7. T. J. Cole, M. C. Bellizzi, K. M. Flegal, and W. H. Dietz, “Establishing a standard definition for child overweight and obesity worldwide: international survey,” British Medical Journal, vol. 320, no. 7244, pp. 1240–1243, 2000.
  8. R. J. Kuczmarski, C. L. Ogden, and C. L. Ogden, “CDC growth charts: United States,” Advance Data, no. 314, pp. 1–27, 2000.
  9. K. M. Flegal, R. Wei, and C. Ogden, “Weight-for-stature compared with body mass index-for-age growth charts for the United States from the Centers for Disease Control and Prevention,” American Journal of Clinical Nutrition, vol. 75, no. 4, pp. 761–766, 2002.
  10. K. G. M. M. Alberti and P. Z. Zimmet, “Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation,” Diabetic Medicine, vol. 15, no. 7, pp. 539–553, 1998.
  11. B. Balkau and M. A. Charles, “Comment on the provisional report from the WHO consultation,” Diabetic Medicine, vol. 16, no. 5, pp. 442–443, 1999. View at Publisher · View at Google Scholar
  12. “Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report,” Circulation, vol. 106, no. 25, pp. 3143–3421, 2002.
  13. K. G. M. M. Alberti, P. Zimmet, and J. Shaw, “Metabolic syndrome—a new world-wide definition. A consensus statement from the International Diabetes Federation,” Diabetic Medicine, vol. 23, no. 5, pp. 469–480, 2006. View at Publisher · View at Google Scholar · View at PubMed
  14. S. M. Grundy, J. I. Cleeman, and J. I. Cleeman, “Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement,” Circulation, vol. 112, no. 17, pp. 2735–2752, 2005. View at Publisher · View at Google Scholar · View at PubMed
  15. A. Robert, R. H. Eckel, and R. H. Eckel, “Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National heart, lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; And international association for the study of obesity,” Circulation, vol. 120, no. 16, pp. 1640–1645, 2009. View at Publisher · View at Google Scholar · View at PubMed
  16. E. Goodman, S. R. Daniels, J. B. Meigs, and L. M. Dolan, “Instability in the diagnosis of metabolic syndrome in adolescents,” Circulation, vol. 115, no. 17, pp. 2316–2322, 2007. View at Publisher · View at Google Scholar · View at PubMed
  17. S. S. Sun, R. Liang, and R. Liang, “Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study,” Journal of Pediatrics, vol. 152, no. 2, pp. 191–200, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. Z. H. Beg, D. W. Allmann, and D. M. Gibson, “Modulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol,” Biochemical and Biophysical Research Communications, vol. 54, no. 4, pp. 1362–1369, 1973. View at Scopus
  19. C. A. Carlson and K. H. Kim, “Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation,” Journal of Biological Chemistry, vol. 248, no. 1, pp. 378–380, 1973. View at Scopus
  20. D. G. Hardie, J. W. Scott, D. A. Pan, and E. R. Hudson, “Management of cellular energy by the AMP-activated protein kinase system,” FEBS Letters, vol. 546, no. 1, pp. 113–120, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. M. E. Osler and J. R. Zierath, “Minireview: adenosine 5′-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle,” Endocrinology, vol. 149, no. 3, pp. 935–941, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. M. W. Schwartz, S. C. Woods, D. Porte Jr., R. J. Seeley, and D. G. Baskin, “Central nervous system control of food intake,” Nature, vol. 404, no. 6778, pp. 661–671, 2000. View at Scopus
  23. M. R. Druce, C. J. Small, and S. R. Bloom, “Minireview: gut peptides regulating satiety,” Endocrinology, vol. 145, no. 6, pp. 2660–2665, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. C. L. Roth, P. J. Enriori, K. Harz, J. Woelfle, M. A. Cowley, and T. Reinehr, “Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 12, pp. 6386–6391, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. M. W. Furnes, C. M. Zhao, B. Stenstrom, C. J. Arum, K. Tommeras, B. Kulseng, and D. Chen, “Feeding behavior and body weight development: lessons from rats subjected to gastric bypass surgery or high-fat diet,” Journal of Physiology and Pharmacology, vol. 60, 7, pp. 25–31, 2009.
  26. R. Granata, F. Settanni, and F. Settanni, “Obestatin promotes survival of pancreatic β-cells and human islets and induces expression of genes involved in the regulation of β-cell mass and function,” Diabetes, vol. 57, no. 4, pp. 967–979, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. F. Cordido, M. L. Isidro, R. Nemiña, and S. Sangiao-Alvarellos, “Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect,” Current Drug Discovery Technologies, vol. 6, no. 1, pp. 34–42, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Gil-Campos, C. M. Aguilera, R. Cañete, and A. Gil, “Ghrelin: a hormone regulating food intake and energy homeostasis,” British Journal of Nutrition, vol. 96, no. 2, pp. 201–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. R. J. A. James, R. F. Drewett, and T. D. Cheetham, “Low cord ghrelin levels in term infants are associated with slow weight gain over the first 3 months of life,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 8, pp. 3847–3850, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. F. Darendeliler, F. Bas, and F. Bas, “Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth,” European Journal of Endocrinology, vol. 159, no. 5, pp. 555–560, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. F. Darendeliler, S. Poyrazoglu, F. Bas, O. Sancakli, and G. Gokcay, “Ghrelin levels are decreased in non-obese prepubertal children born large for gestational age,” European Journal of Endocrinology, vol. 160, no. 6, pp. 951–956, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. C. Maffeis, R. C. Bonadonna, and R. C. Bonadonna, “Ghrelin, insulin sensitivity and postprandial glucose disposal in overweight and obese children,” European Journal of Endocrinology, vol. 154, no. 1, pp. 61–68, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. S. Bellone, N. Castellino, and N. Castellino, “Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 4, pp. 1662–1665, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Murdolo, P. Lucidi, and P. Lucidi, “Insulin is required for prandial ghrelin suppression in humans,” Diabetes, vol. 52, no. 12, pp. 2923–2927, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Bacha and S. A. Arslanian, “Ghrelin suppression in overweight children: a manifestation of insulin resistance?” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 5, pp. 2725–2730, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. H. H. M. Maes, M. C. Neale, and L. J. Eaves, “Genetic and environmental factors in relative body weight and human adiposity,” Behavior Genetics, vol. 27, no. 4, pp. 325–351, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. C. T. Montague, I. S. Farooqi, and I. S. Farooqi, “Congenital leptin deficiency is associated with severe early-onset obesity in humans,” Nature, vol. 387, no. 6636, pp. 903–908, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. I. Sadaf Farooqi, G. Matarese, and G. Matarese, “Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency,” Journal of Clinical Investigation, vol. 110, no. 8, pp. 1093–1103, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Strobel, T. Issad, L. Camoin, M. Ozata, and A. D. Strosberg, “A leptin missense mutation associated with hypogonadism and morbid obesity,” Nature Genetics, vol. 18, no. 3, pp. 213–215, 1998. View at Scopus
  40. W. T. Gibson, I. S. Farooqi, M. Moreau, A. M. DePaoli, E. Lawrence, S. O'Rahilly, and R. A. Trussell, “Congenital leptin deficiency due to homozygosity for the Δ133G mutation: report of another case and evaluation of response to four years of leptin therapy,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 10, pp. 4821–4826, 2004. View at Publisher · View at Google Scholar · View at PubMed
  41. L. Pérusse, T. Rankinen, and T. Rankinen, “The human obesity gene map: the 2004 update,” Obesity Research, vol. 13, no. 3, pp. 381–490, 2005. View at Scopus
  42. C. Menzaghi, T. Ercolino, and T. Ercolino, “A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome,” Diabetes, vol. 51, no. 7, pp. 2306–2312, 2002. View at Scopus
  43. E. Filippi, F. Sentinelli, and F. Sentinelli, “Association of the human adiponectin gene and insulin resistance,” European Journal of Human Genetics, vol. 12, no. 3, pp. 199–205, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. O. Ukkola , T. Rankinen, S.J. Weisnagel, et al., “Interactions among the α2- and β2 adrenoreceptor genes and regional fat distribution in humans: association and linkage studies,” Obesity Research, vol. 3, pp. 249–255, 1995. View at Scopus
  45. C. Garenc, L. Pérusse, and L. Pérusse, “The α2-adrenergic receptor gene and body fat content and distribution: the HERITAGE family study,” Molecular Medicine, vol. 8, no. 2, pp. 88–94, 2002. View at Scopus
  46. O. Mammès, D. Betoulle, and D. Betoulle, “Novel polymorphisms in the 5' region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity,” Diabetes, vol. 47, no. 3, pp. 487–489, 1998. View at Publisher · View at Google Scholar · View at Scopus
  47. O. Mammès, D. Betoulle, R. Aubert, B. Herbeth, G. Siest, and F. Fumeron, “Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight,” Annals of Human Genetics, vol. 64, no. 5, pp. 391–394, 2000. View at Publisher · View at Google Scholar · View at Scopus
  48. W.-D. Li, D. R. Reed, J. H. Lee, W. Xu, R. L. Kilker, B. R. Sodam, and R. A. Price, “Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women,” Annals of Human Genetics, vol. 63, no. 3, pp. 227–234, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. R. Roussel, A. F. Reis, D. Dubois-Laforgue, C. Bellanné-Chantelot, J. Timsit, and G. Velho, “The N363S polymorphism in the glucocorticoid receptor gene is associated with overweight in subjects with type 2 diabetes mellitus,” Clinical Endocrinology, vol. 59, no. 2, pp. 237–241, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Ek, S. A. Urhammer, T. I. A. Sørensen, T. Andersen, J. Auwerx, and O. Pedersen, “Homozygosity of the Pro12Ala variant of the peroxisome proliferation- activated receptor-γ2 (PPAR-γ2): divergent modulating effects on body mass index in obese and lean Caucasian men,” Diabetologia, vol. 42, no. 7, pp. 892–895, 1999. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Öhman, L. Oksanen, and L. Oksanen, “Genome-wide scan of obesity in finnish sibpairs reveals linkage to chromosome Xq24,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 9, pp. 3183–3190, 2000. View at Scopus
  52. D. J. P. Barker, “Fetal origins of coronary heart disease,” British Medical Journal, vol. 311, no. 6998, pp. 171–174, 1995. View at Scopus
  53. T. P. Fleming, W. Y. Kwong, and W. Y. Kwong, “The embryo and its future,” Biology of Reproduction, vol. 71, no. 4, pp. 1046–1054, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. M. H. Vickers, S. Reddy, B. A. Ikenasio, and B. H. Breier, “Dysregulation of the adipoinsular axis—a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming,” Journal of Endocrinology, vol. 170, no. 2, pp. 323–332, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. S. J. Roza, E. A. P. Steegers, and E. A. P. Steegers, “What is spared by fetal brain-sparing? Fetal circulatory redistribution and behavioral problems in the general population,” American Journal of Epidemiology, vol. 168, no. 10, pp. 1145–1152, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  56. P. J. Rozance, S. W. Limesand, J. S. Barry, L. D. Brown, and W. W. Hay Jr., “Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction,” Pediatric Research, vol. 65, no. 1, pp. 72–78, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  57. D. Jaquet, J. Leger, C. Levy-Marchal, J. F. Oury, and P. Czernichow, “Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 4, pp. 1243–1246, 1998. View at Publisher · View at Google Scholar · View at Scopus
  58. I. C. McMillen, B. S. Muhlhausler, J. A. Duffield, and B. S. J. Yuen, “Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth,” Proceedings of the Nutrition Society, vol. 63, no. 3, pp. 405–412, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. J. M. Wallace, R. P. Aitken, J. S. Milne, and W. W. Hay Jr., “Nutritionally mediated placental growth restriction in the growing adolescent: consequences for the fetus,” Biology of Reproduction, vol. 71, no. 4, pp. 1055–1062, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. D. Jaquet, J. Leger, C. Levy-Marchal, J. F. Oury, and P. Czernichow, “Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 4, pp. 1243–1246, 1998. View at Publisher · View at Google Scholar · View at Scopus
  61. M. H. Vickers, B. H. Breier, W. S. Cutfield, P. L. Hofman, and P. D. Gluckman, “Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition,” American Journal of Physiology, vol. 279, no. 1, pp. E83–E87, 2000. View at Scopus
  62. J. E. Ekert, K. L. Gatford, B. G. Luxford, R. G. Campbell, and P. C. Owens, “Leptin expression in offspring is programmed by nutrition in pregnancy,” Journal of Endocrinology, vol. 165, no. 3, pp. R1–R6, 2000. View at Scopus
  63. L. Thomas, J. M. Wallace, R. P. Aitken, J. G. Mercer, P. Trayhurn, and N. Hoggard, “Circulating leptin during ovine pregnancy in relation to maternal nutrition, body composition and pregnancy outcome,” Journal of Endocrinology, vol. 169, no. 3, pp. 465–476, 2001. View at Publisher · View at Google Scholar · View at Scopus
  64. R. A. Ehrhardt, A. W. Bell, and Y. R. Boisclair, “Spatial and developmental regulation of leptin in fetal sheep,” American Journal of Physiology, vol. 282, no. 6, pp. R1628–R1635, 2002. View at Scopus
  65. B. S. Mühlhäusler, C. T. Roberts, J. R. McFarlane, K. G. Kauter, and I. C. McMillen, “Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements,” Biology of Reproduction, vol. 67, no. 2, pp. 493–499, 2002. View at Scopus
  66. B. S. Mühlhäusler, C. T. Roberts, and C. T. Roberts, “Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in Well-Nourished ewes in late pregnancy,” Endocrinology, vol. 144, no. 11, pp. 4947–4954, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  67. D. S. Gardner, K. Tingey, and K. Tingey, “Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition,” American Journal of Physiology, vol. 289, no. 4, pp. R947–R954, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. S. P. Ford, B. W. Hess, and B. W. Hess, “Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring,” Journal of Animal Science, vol. 85, no. 5, pp. 1285–1294, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. H. V. Petersen, M. Peshavaria, A. A. Pedersen, J. Philippe, R. Stein, O. D. Madsen, and P. Serup, “Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor,” FEBS Letters, vol. 431, no. 3, pp. 362–366, 1998. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Desai, G. H. , M. Ferelli, N. Kallichanda, and R. H. Lane, “Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring,” Reproductive Sciences, vol. 15, no. 8, pp. 785–796, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. R. F. Thompson, M. J. Fazzari, H. Niu, N. Barzilai, R. A. Simmons, and J. M. Greally, “Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats,” Journal of Biological Chemistry, vol. 285, no. 20, pp. 15111–15118, 2010. View at Publisher · View at Google Scholar · View at PubMed
  72. S. W. Limesand, J. Jensen, J. C. Hutton, and W. W. Hay Jr., “Diminished β-cell replication contributes to reduced β-cell mass in fetal sheep with intrauterine growth restriction,” American Journal of Physiology, vol. 288, no. 5, pp. R1297–R1305, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  73. S. R. Thorn, T. R. H. Regnault, and T. R. H. Regnault, “Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle,” Endocrinology, vol. 150, no. 7, pp. 3021–3030, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  74. F. Delahaye, C. Breton, and C. Breton, “Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups,” Endocrinology, vol. 149, no. 2, pp. 470–475, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. C. Breton, M.-A. Lukaszewski, and M.-A. Lukaszewski, “Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring,” American Journal of Physiology, vol. 296, no. 3, pp. E462–E472, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  76. K. E. Warnes, M. J. Morris, M. E. Symonds, I. D. Phillips, I. J. Clarke, J. A. Owens, and I. C. McMillen, “Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic Neuropeptide Y expression in the sheep fetus,” Journal of Neuroendocrinology, vol. 10, no. 1, pp. 51–57, 2008.
  77. A. J. W. Fletcher, C. M. B. Edwards, D. S. Gardner, A. L. Fowden, and D. A. Giussani, “Neuropeptide Y in the sheep fetus: effects of acute hypoxemia and dexamethasone during late gestation,” Endocrinology, vol. 141, no. 11, pp. 3976–3982, 2000. View at Scopus
  78. C. T. Huizinga, C. B. M. Oudejans, and H. A. Delemarre-van de Waal, “Persistent changes in somatostatin and neuropeptide Y mRNA levels but not in growth hormone-releasing hormone mRNA levels in adult rats after intrauterine growth retardation,” Journal of Endocrinology, vol. 168, no. 2, pp. 273–281, 2001. View at Publisher · View at Google Scholar · View at Scopus
  79. S. G. Bouret, “Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development,” Journal of Nutrition, vol. 140, no. 3, pp. 653–657, 2010. View at Publisher · View at Google Scholar · View at PubMed
  80. B. Coupé, V. Amarger, I. Grit, A. Benani, and P. Parnet, “Nutritional programming affects hypothalamic organization and early response to leptin,” Endocrinology, vol. 151, no. 2, pp. 702–713, 2010. View at Publisher · View at Google Scholar · View at PubMed
  81. N. Freinkel, “Of pregnancy and progeny,” Diabetes, vol. 29, no. 12, pp. 1023–1035, 1980. View at Scopus
  82. D. J. Pettitt, W. C. Knowler, H. R. Baird, and P. H. Bennett, “Gestational diabetes: infant and maternal complications of pregnancy in relation to third-trimester glucose tolerance in the Pima Indians,” Diabetes Care, vol. 3, no. 3, pp. 458–464, 1980. View at Scopus
  83. P. W. Franks, H. C. Looker, S. Kobes, L. Touger, P. A. Tataranni, R. L. Hanson, and W. C. Knowler, “Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring,” Diabetes, vol. 55, no. 2, pp. 460–465, 2006. View at Publisher · View at Google Scholar · View at Scopus
  84. L. Touger, H. C. Looker, J. Krakoff, R. S. Lindsay, V. Cook, and W. C. Knowler, “Early growth in offspring of diabetic mothers,” Diabetes Care, vol. 28, no. 3, pp. 585–589, 2005. View at Publisher · View at Google Scholar · View at Scopus
  85. D. R. McCance, D. J. Pettitt, R. L. Hanson, L. T. H. Jacobsson, W. C. Knowler, and P. H. Bennett, “Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype?” British Medical Journal, vol. 308, no. 6934, pp. 942–945, 1994. View at Scopus
  86. J. A. Westgate, R. S. Lindsay, and R. S. Lindsay, “Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand,” Diabetes Care, vol. 29, no. 6, pp. 1345–1350, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  87. A. K. Rao, K. Daniels, Y. Y. El-Sayed, M. K. Moshesh, and A. B. Caughey, “Perinatal outcomes among Asian American and Pacific Islander women,” American Journal of Obstetrics and Gynecology, vol. 195, no. 3, pp. 834–838, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  88. D. Simmons and B. H. Breier, “Fetal overnutrition in polynesian pregnancies and in gestational diabetes may lead to dysregulation of the adipoinsular axis in offspring,” Diabetes Care, vol. 25, no. 9, pp. 1539–1544, 2002. View at Publisher · View at Google Scholar · View at Scopus
  89. I. C. McMillen, B. S. Muhlhausler, J. A. Duffield, and B. S. J. Yuen, “Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth,” Proceedings of the Nutrition Society, vol. 63, no. 3, pp. 405–412, 2004. View at Publisher · View at Google Scholar · View at Scopus
  90. M. J. Zhu, B. Han, and B. Han, “AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep,” Journal of Physiology, vol. 586, no. 10, pp. 2651–2664, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  91. L. K. Philp, B. S. Muhlhausler, A. Janovska, G. A. Wittert, J. A. Duffield, and I. C. McMillen, “Maternal overnutrition suppresses the phosphorylation of 5-AMP-activated protein kinase in liver, but not skeletal muscle, in the fetal and neonatal sheep,” American Journal of Physiology, vol. 295, no. 6, pp. R1982–R1990, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  92. M. Du, X. Yan, J. F. Tong, J. Zhao, and M. J. Zhu, “Maternal obesity, inflammation, and fetal skeletal muscle development,” Biology of Reproduction, vol. 82, no. 1, pp. 4–12, 2010. View at Publisher · View at Google Scholar · View at PubMed
  93. M. H. Vickers, P. D. Gluckman, and P. D. Gluckman, “Neonatal leptin treatment reverses developmental programming,” Endocrinology, vol. 146, no. 10, pp. 4211–4216, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  94. M. H. Vickers, P. D. Gluckman, and P. D. Gluckman, “The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy,” Endocrinology, vol. 149, no. 4, pp. 1906–1913, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  95. C. S. Wyrwoll, P. J. Mark, T. A. Mori, I. B. Puddey, and B. J. Waddell, “Prevention of programmed hyperleptinemia and hypertension by postnatal dietary ω-3 fatty acids,” Endocrinology, vol. 147, no. 1, pp. 599–606, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  96. E. Zambrano, P. M. Martínez-Samayoa, G. L. Rodríguez-González, and P. W. Nathanielsz, “Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats,” Journal of Physiology, vol. 588, no. 10, pp. 1791–1799, 2010. View at Publisher · View at Google Scholar · View at PubMed
  97. R. Resnik, “Intrauterine growth restriction,” Obstetrics and Gynecology, vol. 99, no. 3, pp. 490–496, 2002. View at Publisher · View at Google Scholar · View at Scopus
  98. M. S. Kramer, “The epidemiology of adverse pregnancy outcomes: an overview,” Journal of Nutrition, vol. 133, no. 5, 2003. View at Scopus
  99. F. Galtier-Dereure, C. Boegner, and J. Bringer, “Obesity and pregnancy: complications and cost,” American Journal of Clinical Nutrition, vol. 71, no. 5, pp. 1242S–1248S, 2000. View at Scopus
  100. J. M. Ordovas and V. Mooser, “Nutrigenomics and nutrigenetics,” Current Opinion in Lipidology, vol. 15, no. 2, pp. 101–108, 2004. View at Publisher · View at Google Scholar · View at Scopus
  101. M. R. Freedman, J. King, and E. Kennedy, “Popular diets: a scientific review,” Obesity Research, vol. 9, supplement 1, pp. 1S–40S, 2001. View at Scopus
  102. A. Raben, I. Macdonald, and A. Astrup, “Replacement of dietary fat by sucrose or starch: effects on 14d ad libitum energy intake, energy expenditure and body weight in formerly obese and never-obese subjects,” International Journal of Obesity, vol. 21, no. 10, pp. 846–859, 1997.
  103. C. B. Blum and R. I. Levy, “Role of dietary intervention in the primary prevention of coronary heart disease. Individuals with high-normal or elevated serum cholesterol levels should be placed on cholesterol-lowering diets,” Cardiology, vol. 74, no. 1, pp. 2–21, 1987.
  104. R. Atkins, Dr Atkins' New Diet Revolution, Harper Collins, New York, NY, USA, 2002.
  105. M. Porrini, A. Santangelo, R. Crovetti, P. Riso, G. Testolin, and J. E. Blundell, “Weight, protein, fat, and timing of preloads affect food intake,” Physiology and Behavior, vol. 62, no. 3, pp. 563–570, 1997. View at Publisher · View at Google Scholar · View at Scopus
  106. M. J. Sharman, A. L. Gómez, W. J. Kraemer, and J. S. Volek, “Very low carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men,” Journal of Nutrition, vol. 134, no. 4, pp. 880–885, 2004. View at Scopus
  107. D. M. Bravata, L. Sanders, J. Huang, et al., “Efficacy and safety of low-carbohydrate diets,” Journal of the American Medical Association, vol. 289, no. 14, pp. 1837–1850, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  108. P. A. Astrup, D. T. Meinert Larsen, and A. Harper, “Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?” The Lancet, vol. 364, no. 9437, pp. 897–899, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  109. R. F. Kushner and B. Doerfler, “Low-carbohydrate, high-protein diets revisited,” Current Opinion in Gastroenterology, vol. 24, no. 2, pp. 198–203, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  110. B. J. Brehm and D. A. D'Alessio, “Benefits of high-protein weight loss diets: enough evidence for practice?” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 15, no. 5, pp. 416–421, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  111. V. S. Malik and F. B. Hu, “Popular weight-loss diets: from evidence to practice,” Nature Review Cardiology, vol. 4, no. 1, pp. 34–41, 2007.
  112. D. G. Hardie, S. A. Hawley, and J. W. Scott, “AMP-activated protein kinase—development of the energy sensor concept,” Journal of Physiology, vol. 574, no. 1, pp. 7–15, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  113. M. H. Tschöp, D. Y. Hui, and T. L. Horvath, “Diet-induced leptin resistance: the heart of the matter,” Endocrinology, vol. 148, no. 3, pp. 921–923, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  114. J. D. McGarry, “Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes,” Diabetes, vol. 51, no. 1, pp. 7–18, 2002.
  115. Y. Liu, Q. Wan, Q. Guan, L. Gao, and J. Zhao, “High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle,” Biochemical and Biophysical Research Communications, vol. 339, no. 2, pp. 701–707, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  116. M. Daval, F. Foufelle, and P. Ferré, “Functions of AMP-activated protein kinase in adipose tissue,” Journal of Physiology, vol. 574, no. 1, pp. 55–62, 2006. View at Publisher · View at Google Scholar · View at PubMed
  117. T. L. Martin, T. Alquier, K. Asakura, N. Furukawa, F. Preitner, and B. B. Kahn, “Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle,” Journal of Biological Chemistry, vol. 281, no. 28, pp. 18933–18941, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  118. E. B. Taylor, W. J. Ellingson, J. D. Lamb, D. G. Chesser, and W. W. Winder, “Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25,” American Journal of Physiology, vol. 288, no. 6, pp. E1055–E1061, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  119. J. Ruzickova, M. Rossmeisl, and M. Rossmeisl, “Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue,” Lipids, vol. 39, no. 12, Article ID L9552, pp. 1177–1185, 2004. View at Publisher · View at Google Scholar · View at Scopus
  120. C. H. S. Ruxton, S. C. Reed, M. J. A. Simpson, and K. J. Millington, “The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence,” Journal of Human Nutrition and Dietetics, vol. 17, no. 5, pp. 449–459, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  121. P. J. Nestel, W. E. Connor, and M. F. Reardon, “Suppression by diets rich in fish oil of very low density lipoprotein production in man,” Journal of Clinical Investigation, vol. 74, no. 1, pp. 82–89, 1984. View at Scopus
  122. V. Kus, T. Prazak, and T. Prazak, “Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance,” American Journal of Physiology, vol. 295, no. 2, pp. E356–E367, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  123. G. Suchankova, M. Tekle, A. K. Saha, N. B. Ruderman, S. D. Clarke, and T. W. Gettys, “Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats,” Biochemical and Biophysical Research Communications, vol. 326, no. 4, pp. 851–858, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  124. M.-Y. Wang and R. H. Unger, “Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone,” American Journal of Physiology, vol. 288, no. 1, pp. E216–E221, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  125. P. Flachs, V. Mohamed-Ali, and V. Mohamed-Ali, “Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet,” Diabetologia, vol. 49, no. 2, pp. 394–397, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  126. L. -S. Wang, Y. -W. Huang, and Y. -W. Huang, “Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene,protein tyrosine phosphatase gamma (PTPgama),in human breast cells,” Anticancer Research, vol. 26, no. 1, pp. 27–34, 2006.
  127. D. Kritchevsky, S. A. Tepper, S. Wright, S. K. Czarnecki, T. A. Wilson, and R. J. Nicolosi, “Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions,” Lipids, vol. 39, no. 7, pp. 611–616, 2004. View at Publisher · View at Google Scholar · View at Scopus
  128. M. H. H. So, I. M. Y. Tse, and E. T. S. Li, “Dietary fat concentration influences the effects of trans-10, cis-12 conjugated linoleic acid on temporal patterns of energy Intake and Hypothalamic expression of appetite-controlling genes in Mice,” Journal of Nutrition, vol. 139, no. 1, pp. 145–151, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  129. M.-C. Beauvieux, H. Roumes, N. Robert, H. Gin, V. Rigalleau, and J.-L. Gallis, “Butyrate ingestion improves hepatic glycogen storage in the re-fed rat,” BMC Physiology, vol. 8, no. 1, article 19, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  130. S. Sakakibara, T. Yamauchi, Y. Oshima, Y. Tsukamoto, and T. Kadowaki, “Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice,” Biochemical and Biophysical Research Communications, vol. 344, no. 2, pp. 597–604, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  131. T. Kawaguchi, K. Osatomi, H. Yamashita, T. Kabashima, and K. Uyeda, “Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase,” Journal of Biological Chemistry, vol. 277, no. 6, pp. 3829–3835, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  132. Z. Gao, J. Yin, and J. Yin, “Butyrate improves insulin sensitivity and increases energy expenditure in mice,” Diabetes, vol. 58, no. 7, pp. 1509–1517, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  133. J. M. Warren and C. Jeya, “Children low glycemic index breakfasts and reduced food intake in preadolescent,” Pediatrics, vol. 112, no. 5, p. e414, 2003. View at Scopus
  134. H. Ford and G. Frost, “Glycaemic index, appetite and body weight,” Proceedings of the Nutrition Society, vol. 69, no. 2, pp. 199–203, 2010. View at Publisher · View at Google Scholar · View at PubMed
  135. C. Cantó, Z. Gerhart-Hines, and Z. Gerhart-Hines, “AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity,” Nature, vol. 458, no. 7241, pp. 1056–1060, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  136. G. Blander and L. Guarente, “The Sir2 family of protein deacetylases,” Annual Review of Biochemistry, vol. 73, pp. 417–435, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  137. A. Fukuhara, M. Matsuda, and M. Matsuda, “Visfatin: a protein secreted by visceral fat that Mimics the effects of insulin,” Science, vol. 307, no. 5708, pp. 426–430, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  138. M. Fulco, Y. Cen, P. Zhao, E. P. Hoffman, M. W. McBurney, A. A. Sauve, and V. Sartorelli, “Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt,” Developmental Cell, vol. 14, no. 5, pp. 661–673, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  139. M. Fulco and V. Sartorelli, “Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues,” Cell Cycle, vol. 7, no. 23, pp. 3669–3679, 2008. View at Scopus
  140. K. Moller, R. Krogh-Madsen, et al., “Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet,” New England Journal of Medicine, vol. 359, no. 20, p. 2170, 2008.
  141. T. L. Halton and F. B. Hu, “The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review,” Journal of the American College of Nutrition, vol. 23, no. 5, pp. 373–385, 2004. View at Scopus
  142. D. W. Gietzen, S. Hao, and T. G. Anthony, “Mechanisms of food intake repression in indispensable amino acid deficiency,” Annual Review of Nutrition, vol. 27, pp. 63–78, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  143. M. Potier, N. Darcel, and D. Tomé, “Protein, amino acids and the control of food intake,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 1, pp. 54–58, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  144. J. C. G. Halford, J. A. Harrold, E. J. Boyland, C. L. Lawton, and J. E. Blundell, “Serotonergic drugs: effects on appetite expression and use for the treatment of obesity,” Drugs, vol. 67, no. 1, pp. 27–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  145. C. D. Morrison, A. Xi, C. L. White, J. Ye, and R. J. Martin, “Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism,” American Journal of Physiology, vol. 293, no. 1, pp. E165–E171, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  146. E. R. Ropelle, J. R. Pauli, and J. R. Pauli, “A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamyein (mTOR) in high-protein diet-induced weight loss,” Diabetes, vol. 57, no. 3, pp. 594–605, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  147. C. E. Gleason, D. Lu, L. A. Witters, C. B. Newgard, and M. J. Birnbaum, “The role of AMPK and mTOR in nutrient sensing in pancreatic β-cells,” Journal of Biological Chemistry, vol. 282, no. 14, pp. 10341–10351, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  148. J. K. Grover and S. P. Yadav, “Pharmacological actions and potential uses of Momordica charantia: a review,” Journal of Ethnopharmacology, vol. 93, no. 1, pp. 123–132, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  149. M. -J. Tan, J. -M. Ye, and J. -M. Ye, “Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway,” Chemistry and Biology, vol. 15, no. 3, pp. 263–273, 2008. View at Publisher · View at Google Scholar · View at PubMed
  150. J. A. Baur, K. J. Pearson, and K. J. Pearson, “Resveratrol improves health and survival of mice on a high-calorie diet,” Nature, vol. 444, no. 7117, pp. 337–342, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  151. M. Lagouge, C. Argmann, and C. Argmann, “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α,” Cell, vol. 127, no. 6, pp. 1109–1122, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  152. S.-H. Leng, F.-E. Lu, and L.-J. Xu, “Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion,” Acta Pharmacologica Sinica, vol. 25, no. 4, pp. 496–502, 2004. View at Scopus
  153. W. S. Kim, Y. S. Lee, and Y. S. Lee, “Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity,” American Journal of Physiology, vol. 296, no. 4, pp. E812–E819, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  154. Y. S. Lee, W. S. Kim, and W. S. Kim, “Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states,” Diabetes, vol. 55, no. 8, pp. 2256–2264, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  155. S. S. Gidding, B. A. Dennison, and B. A. Dennison, “Dietary recommendations for children and adolescents: a guide for practitioners,” Pediatrics, vol. 117, no. 2, pp. 544–559, 2006. View at Publisher · View at Google Scholar · View at PubMed
  156. L. J. Gibson, J. Peto, J. M. Warren, and I. dos Santos Silva, “Lack of evidence on diets for obesity for children: a systematic review,” International Journal of Epidemiology, vol. 35, no. 6, pp. 1544–1552, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  157. H. Mendieta-Zerón, M. López, and C. Diéguez, “Hypothalamic regulation of feeding by nutrients and metabolic state,” Revista Espanola de Obesidad, vol. 5, no. 6, pp. 351–362, 2007. View at Scopus
  158. B. A. Spear, S. E. Barlow, C. Ervin, D. S. Ludwig, B. E. Saelens, K. E. Schetzina, and E. M. Taveras, “Recommendations for treatment of child and adolescent overweight and obesity,” Pediatrics, vol. 120, pp. S254–288, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  159. G. P. August, S. Caprio, and S. Caprio, “Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 12, pp. 4576–4599, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  160. L. H. Oude, L. Baur, H. Jansen, V. A. Shrewsbury, C. O'Malley, R. P. Stolk, and C. D. Summerbell, “Interventions for treating obesity in children,” Cochrane Database of Systematic Reviews, vol. 21, no. 1, Article ID CD001872, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  161. J. R. McDuffie, K. A. Calis, G. I. Uwaifo, N. G. Sebring, E. M. Fallon, V. S. Hubbard, and J. A. Yanovski, “Three-month tolerability of orlistat in adolescents with obesity-related comorbid conditions,” Obesity Research, vol. 10, no. 7, pp. 642–650, 2002. View at Scopus
  162. S. Norgren, P. Danielsson, R. Jurold, M. Lötborn, and C. Marcus, “Orlistat treatment in obese prepubertal children: a pilot study,” Acta Paediatrica, International Journal of Paediatrics, vol. 92, no. 6, pp. 666–670, 2003. View at Publisher · View at Google Scholar · View at Scopus
  163. W. Y. S. Leung, G. N. Thomas, J. C. N. Chan, and B. Tomlinson, “Weight management and current options in pharmacotherapy: orlistat and sibutramine,” Clinical Therapeutics, vol. 25, no. 1, pp. 58–80, 2003. View at Publisher · View at Google Scholar · View at Scopus
  164. R. I. Berkowitz, K. Fujioka, and K. Fujioka, “Effects of sibutramine treatment in obese adolescents: a randomized trial,” Annals of Internal Medicine, vol. 145, no. 2, pp. 81–90, 2006. View at Scopus
  165. G. Zhou, R. Myers, and R. Myers, “Role of AMP-activated protein kinase in mechanism of metformin action,” Journal of Clinical Investigation, vol. 108, no. 8, pp. 1167–1174, 2001. View at Publisher · View at Google Scholar · View at Scopus
  166. G. Marchesini, M. Brizi, G. Bianchi, S. Tomassetti, M. Zoli, and N. Melchionda, “Metformin in non-alcoholic steatohepatitis,” The Lancet, vol. 358, no. 9285, pp. 893–894, 2001. View at Publisher · View at Google Scholar · View at Scopus
  167. R. Pasquali, A. Gambineri, and A. Gambineri, “Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 8, pp. 2767–2774, 2000. View at Publisher · View at Google Scholar · View at Scopus
  168. M. Freemark and D. Bursey, “The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes,” Pediatrics, vol. 107, no. 4, p. e55, 2001. View at Scopus
  169. S. Srinivasan, G. R. Ambler, and G. R. Ambler, “Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, pp. 2074–2080, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  170. T. S. Burgert, E. J. Duran, and E. J. Duran, “Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance,” Pediatric Diabetes, vol. 9, no. 6, pp. 567–576, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  171. K. Love-Osborne, J. Sheeder, and P. Zeitler, “Addition of metformin to a lifestyle modification program in adolescents with insulin resistance,” Journal of Pediatrics, vol. 152, no. 6, pp. 817–822, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  172. K. Casteels, S. Fieuws, and S. Fieuws, “Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit,” Pediatric Diabetes, vol. 11, no. 1, pp. 61–69, 2010. View at Publisher · View at Google Scholar · View at PubMed
  173. D. M. Wilson, S. H. Abrams, and S. H. Abrams, “Metformin extended release treatment of adolescent obesity,” Archives of Pediatrics and Adolescent Medicine, vol. 164, no. 2, pp. 116–123, 2010. View at Publisher · View at Google Scholar · View at PubMed
  174. A. J. Wilson, H. Prapavessis, and H. Prapavessis, “Lifestyle modification and metformin as long-term treatment options for obese adolescents: study protocol,” BMC Public Health, vol. 9, article 434, 2009. View at Publisher · View at Google Scholar · View at PubMed
  175. M. I. Goran, K. D. Reynolds, and C. H. Lindquist, “Role of physical activity in the prevention of obesity in children,” International Journal of Obesity, vol. 23, no. 3, pp. S18–S33, 1999. View at Scopus
  176. S. R. Daniels, M. S. Jacobson, B. W. McCrindle, R. H. Eckel, and B. M. Sanner, “American heart association childhood obesity: research summit,” Circulation, vol. 119, no. 15, pp. 2114–2123, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  177. C. J. Caspersen, K. E. Powell, and G. Christenson, “Physical activity, exercise and physical fitness: definitions and distinctions for health-related research,” Public Health Reports, vol. 100, no. 2, pp. 126–131, 1985. View at Scopus
  178. A. L. Dunn, R. E. Andersen, and J. M. Jakicic, “Lifestyle physical activity interventions history, short- and long-term effects, and recommendations,” American Journal of Preventive Medicine, vol. 15, no. 4, pp. 398–412, 1998. View at Publisher · View at Google Scholar · View at Scopus
  179. J. Baird, D. Fisher, P. Lucas, J. Kleijnen, H. Roberts, and C. Law, “Being big or growing fast: systematic review of size and growth in infancy and later obesity,” British Medical Journal, vol. 331, no. 7522, pp. 929–931, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  180. N. Stettler, V. A. Stallings, and V. A. Stallings, “Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula,” Circulation, vol. 111, no. 15, pp. 1897–1903, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  181. E. J. Mayer-Davis, S. L. Rifas-Shiman, L. Zhou, F. B. Hu, G. A. Colditz, and M. W. Gillman, “Breast-feeding and risk for childhood obesity: does maternal diabetes or obesity status matter?” Diabetes Care, vol. 29, no. 10, pp. 2231–2237, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  182. D. S. Freedman, L. Kettel Khan, M. K. Serdula, S. R. Srinivasan, and G. S. Berenson, “BMI rebound, childhood height and obesity among adults: the Bogalusa heart study,” International Journal of Obesity, vol. 25, no. 4, pp. 543–549, 2001. View at Publisher · View at Google Scholar · View at Scopus
  183. R. W. Taylor, A. M. Grant, A. Goulding, and S. M. Williams, “Early adiposity rebound: review of papers linking this to subsequent obesity in children and adults,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 8, no. 6, pp. 607–612, 2005.
  184. T. J. Cole, “Children grow and horses race: is the adiposity rebound a critical period for later obesity?” BMC Pediatrics, vol. 4, article no. 6, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  185. J. G. Eriksson, T. Forsén, J. Tuomilehto, C. Osmond, and D. J. P. Barker, “Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life,” Diabetologia, vol. 46, no. 2, pp. 190–194, 2003. View at Scopus
  186. S. Williams and N. Dickson, “Early growth, menarche, and adiposity rebound,” The Lancet, vol. 359, no. 9306, pp. 580–581, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  187. M. F. Rolland-Cachera, M. Deheeger, M. Maillot, and F. Bellisle, “Early adiposity rebound: causes and consequences for obesity in children and adults,” International Journal of Obesity, vol. 30, no. 4, pp. S11–S17, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  188. M. F. Rolland-Cachera, M. Deheeger, M. Guilloud-Bataille, P. Avons, E. Patois, and M. Sempé, “Tracking the development of adiposity from one month of age to adulthood,” Annals of Human Biology, vol. 14, no. 3, pp. 219–229, 1987. View at Scopus
  189. S. M. Williams and A. Goulding, “Patterns of gowth associated with the timing of adiposity rebound,” Obesity, vol. 17, no. 2, pp. 335–341, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  190. S. Williams and N. Dickson, “Early growth, menarche, and adiposity rebound,” The Lancet, vol. 359, no. 9306, pp. 580–581, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  191. S. M. Williams and A. Goulding, “Early adiposity rebound is an important predictor of later obesity,” Obesity, vol. 17, no. 7, p. 1310, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  192. R. C. Whitaker, M. S. Pepe, J. A. Wright, K. D. Seidel, and W. H. Dietz, “Early adiposity rebound and the risk of adult obesity,” Pediatrics, vol. 101, no. 3, p. e5, 1998. View at Scopus
  193. J. G. Eriksson, T. Forsén, J. Tuomilehto, P. D. Winter, C. Osmond, and D. J. P. Barker, “Catch-up growth in childhood and death from coronary heart disease: longitudinal study,” British Medical Journal, vol. 318, no. 7181, pp. 427–431, 1999. View at Scopus
  194. P. Velasquez-Mieyer, S. Perez-Faustineli, and P. A. Cowan, “Identifying children at risk for obesity, type 2 diabetes, and cardiovascular disease,” Diabetes Spectrum, vol. 18, no. 4, pp. 213–220, 2005. View at Publisher · View at Google Scholar
  195. P. R. Nader, M. O'Brien, and M. O'Brien, “Identifying risk for obesity in early childhood,” Pediatrics, vol. 118, no. 3, pp. e594–e601, 2006. View at Publisher · View at Google Scholar · View at PubMed
  196. D. A. Lawlor and N. Chaturvedi, “Treatment and prevention of obesity—are there critical periods for intervention?” International Journal of Epidemiology, vol. 35, no. 1, pp. 3–9, 2006. View at Publisher · View at Google Scholar · View at PubMed
  197. L. L. Moore, D. Gao, and D. Gao, “Does early physical activity predict body fat change throughout childhood?” Preventive Medicine, vol. 37, no. 1, pp. 10–17, 2003. View at Publisher · View at Google Scholar
  198. Physical Activity and Health: A Report from the Surgeon General, US Department of Health and Human Services, Atlanta, Ga, USA, 1996.
  199. L. L. Moore, U. -S.D.T. Nguyen, K. J. Rothman, L. A. Cupples, and R. C. Ellison, “Preschool physical activity level and change in body fatness in young children: the Framingham Children's Study,” American Journal of Epidemiology, vol. 142, no. 9, pp. 982–988, 1995.
  200. M. H. Proctor, L. L. Moore, D. Gao, L. A. Cupples, M. L. Bradlee, M. Y. Hood, and R. C. Ellison, “Television viewing and change in body fat from preschool to early adolescence: the Framingham Children's Study,” International Journal of Obesity, vol. 27, no. 7, pp. 827–833, 2003. View at Publisher · View at Google Scholar · View at PubMed
  201. M. R. Singer, L. L. Moore, E. J. Garrahie, and R. C. Ellison, “The tracking of nutrient intake in young children: the Framingham Children's Study,” American Journal of Public Health, vol. 85, no. 12, pp. 1673–1677, 1995.
  202. C. T. Lim, B. Kola, and M. Korbonits, “AMPK as a mediator of hormonal signaling,” Journal of Molecular Endocrinology, vol. 44, pp. 87–97, 2010.
  203. K. E. Wellen and G. S. Hotamisligil, “Inflammation, stress, and diabetes,” Journal of Clinical Investigation, vol. 115, no. 5, pp. 1111–1119, 2005. View at Publisher · View at Google Scholar
  204. S. J. Schwarzenberg and A. R. Sinaiko, “Obesity and inflammation in children,” Paediatric Respiratory Reviews, vol. 7, no. 4, pp. 239–246, 2006. View at Publisher · View at Google Scholar · View at PubMed
  205. M. Visser, L. M. Bouter, G. M. McQuillan, M. H. Wener, and T. B. Harris, “Low-grade systemic inflammation in overweight children,” Pediatrics, vol. 107, no. 1, pp. 13–20, 2001.
  206. R. Weiss, J. Dziura, and J. Dziura, “Obesity and the metabolic syndrome in children and adolescents,” New England Journal of Medicine, vol. 350, no. 23, pp. 2362–2374, 2004. View at Publisher · View at Google Scholar · View at PubMed
  207. L. Gilardini, P. G. McTernan, A. Girola, N. F. da Silva, L. Alberti, S. Kumar, and C. Invitti, “Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents,” Atherosclerosis, vol. 189, no. 2, pp. 401–407, 2006. View at Publisher · View at Google Scholar · View at PubMed
  208. J. C. Winer, T. L. Zern, and T. L. Zern, “Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 11, pp. 4415–4423, 2006. View at Publisher · View at Google Scholar · View at PubMed
  209. C. Herder, S. Schneitler, and S. Schneitler, “Low-grade inflammation, obesity, and insulin resistance in adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 12, pp. 4569–4574, 2007. View at Publisher · View at Google Scholar · View at PubMed
  210. B. Garanty-Bogacka, M. Syrenicz, A. Syrenicz, A. Gebala, D. Lulka, and M. Walczak, “Serum markers of inflammation and endothelial activation in children with obesity-related hypertension,” Neuroendocrinology Letters, vol. 26, no. 3, pp. 242–246, 2005.
  211. T. Reinehr, B. Stoffel-Wagner, C. L. Roth, and W. Andler, “High-sensitive C-reactive protein, tumor necrosis factor α, and cardiovascular risk factors before and after weight loss in obese children,” Metabolism, vol. 54, no. 9, pp. 1155–1161, 2005. View at Publisher · View at Google Scholar · View at PubMed
  212. M. A. Febbraio and B. K. Pedersen, “Muscle-derived interleukin-6: mechanisms for activation and possible biological roles,” FASEB Journal, vol. 16, no. 11, pp. 1335–1347, 2002. View at Publisher · View at Google Scholar · View at PubMed
  213. B. K. Pedersen and L. Hoffman-Goetz, “Exercise and the immune system: regulation, integration, and adaptation,” Physiological Reviews, vol. 80, no. 3, pp. 1055–1081, 2000.
  214. Anon, “Infant and adult obesity,” The Lancet, vol. 1, no. 7845, pp. 17–18, 1974.
  215. M. Nestle and M. F. Jacobson, “Halting the obesity epidemic: a public policy approach,” Public Health Reports, vol. 115, no. 1, pp. 12–24, 2000.
  216. Department of Health and Human Services (US), Healthy People 2010: Understanding and Improving Health, Government Printing Office, Washington, DC, USA, 2000, Conference edition.
  217. S. E. Barlow, “Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report,” Pediatrics, vol. 120, pp. S164–192, 2007. View at Publisher · View at Google Scholar · View at PubMed
  218. L. Brennan, J. Walkley, S. F. Fraser, K. Greenway, and R. Wilks, “Motivational interviewing and cognitive behaviour therapy in the treatment of adolescent overweight and obesity: study design and methodology,” Contemporary Clinical Trials, vol. 29, no. 3, pp. 359–375, 2008. View at Publisher · View at Google Scholar · View at PubMed
  219. L. Mo-Suwan, S. Pongprapai, C. Junjana, and A. Puetpaiboon, “Effects of a controlled trial of a school-based exercise program on the obesity indexes of preschool children,” American Journal of Clinical Nutrition, vol. 68, no. 5, pp. 1006–1011, 1998.
  220. A. L. Carrel, R. R. Clark, S. E. Peterson, B. A. Nemeth, J. Sullivan, and D. B. Allen, “Improvement of fitness, body composition, and insulin sensitivity in overweight children in a school-based exercise program: a randomized, controlled study,” Archives of Pediatrics and Adolescent Medicine, vol. 159, no. 10, pp. 963–968, 2005. View at Publisher · View at Google Scholar · View at PubMed
  221. M. Dehghan, N. Akhtar-Danesh, and A. T. Merchant, “Childhood obesity, prevalence and prevention,” Nutrition Journal, vol. 4, article 24, 2005. View at Publisher · View at Google Scholar · View at PubMed
  222. J. T. Mallare, A. H. Karabell, P. Velasquez-Mieyer, S. R. S. Stander, and M. L. Christensen, “Current and future treatment of metabolic syndrome and type 2 diabetes in children and adolescents,” Diabetes Spectrum, vol. 18, no. 4, pp. 220–228, 2005. View at Publisher · View at Google Scholar