Ethnic population
(Frequency of A-allele in %)
(Frequency of A-allele in %)Phenotypes Reference Caucasian 340 (46.5) 256 (52.2) Common G-allele predisposed to obesity
Esterbauer et al. 2001 [74 ] 109 (31.2) 589 (38.2) Caucasian 749 (39.6) 816 (40.7) Not associated with obesity or BMI within groups Dalgaard et al. 2003 [60 ] Caucasian 122 (28.2) 374 (29.0) Not associated with obesity or BMI within groups
Mancini et al. 2003 [79 ] 76 (34.9) Caucasian — 302 (32.1) Not associated with BMI within group Sesti et al. 2003 [72 ] Caucasian — 565 (32.4) Not associated with BMI in control or diabetic patients
D’Adamo et al. 2004 [80 ] — 483 (33.6) Japanese — 134 Not associated with BMI, but with hypertension
Ji et al. 2004 [81 ] 342 Caucasian 296 (37.0) — A-allele associated with decreased lipid oxidation Le Fur et al. 2004 [89 ] Caucasian — 327 (34.6) Not associated with BMI within group
Bulotta et al. 2005 [82 ] 746 (28.6) Pima 864 (54.0) — Not associated with BMI within group. AA genotype increased 24 hr EE
Kovacs et al. 2005 [83 ] Indians 263 (55.5) — Korean — 658 Not associated with BMI within group. Associated with decreased HDL-levels Cha et al. 2007 [59 ] Caucasian — 598 Not associated with BMI within group. A-allele associated with decreased W/H-ratio and lower fasting p-insulin
Gable et al. 2007 [84 ] P 653 Filipino — 1755 (29.7) Not associated with BMI within group Marvelle et al. 2008 [85 ] Caucasian 375 (41.3) 2316 (35.8) A-allele associated with obesity and associated with increased risk of CHD and systolic BP. AA genotype associated with increased oxidative stress Dhamrait et al. 2004 [77 ] Caucasian 192 (38.3) 170 (38.2) AA genotype significantly associated with obesity and insulin resistance in children Ochoa et al. 2007 [76 ] Caucasian 225 (39.6) 294 (38.9) AA genotype associated with various indices of obesity Kring et al. 2008 [78 ] Caucasian 277 188 Not associated with early-onset obesity Schäuble et al. 2003 [86 ] Caucasian — 681 (36.9) Not associated with BMI in type 2 diabetic patients, but AA genotype associated with increased triglyceride and cholesterol levels Reis et al. 2004 [90 ] Various — 3784 (35.4–46.7) Not associated with obesity, allele-frequencies not given for obese subjects Hsu et al. 2008 [87 ] Korean — 1469 (~48) GG genotype associated with obesity in children but protective in adults Jun et al. 2009 [75 ] Caucasian — 507 AA genotype decreased total cholesterol and decreased LDL-cholesterol. Not associated with BMI within group Salopuro et al. 2009 [88 ] P Indian 200 (42.0) 240 (32.2) A-allele associated with obesity and hyperinsulinemia (in obese subjects) Srivastava et al. 2010 [91 ]
