Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue
Figure 5
Influence of 8-week oral treatment with semicarbazide on the benzylamine (a) and tyramine (b) oxidation in subcutaneous WAT. Homogenates were preincubated for 15 minutes without (total oxidation, black columns), with 0.5 mM pargyline (in order to determine pargyline-sensitive component as MAO, open columns), or with 1 mM semicarbazide (to determine the semicarbazide-sensitive component as SSAO, shaded columns). Then, they were incubated for 30 minutes in the presence of 0.1 mM benzylamine (a) or 0.5 mM tyramine (b). Mean ± SEM of 6 determinations. Different from corresponding control at , .
