Impact of Weight Loss on Physical Function with Changes in Strength, Muscle Mass, and Muscle Fat Infiltration in Overweight to Moderately Obese Older Adults: A Randomized Clinical Trial
Table 3
Mean changes in anthropometric, body composition, bone mass, muscle strength, and physical function measures from baseline to 6-month followup by intervention group.
Physical Activity + Weight Loss ( = 19)
Physical Activity + Successful Aging ( = 13)
Mean change (BL-6FU)
-value
Mean change (BL-6FU)
-value
Anthropometric
Waist circumference, cm
−4.0 (7.5)#
.03
−1.1 (5.2)
.50
Body weight, kg
−4.9 (4.8)§
<.001
−1.0 (3.5)§
.44
BMI, kg/m2
−1.7 (1.7)§
<.001
−0.4 (1.3)§
.46
DXA
Percent body fat
−2.4 (1.9)§
<.001
−0.05 (1.3)§
.67
Total fat mass, kg
−4.4 (3.2)§
<.001
−0.6 (2.1)§
.27
Total lean mass, kg
−1.5 (1.7)
.001
−0.7 (1.4)
.08
Appendicular lean mass, kg
−0.9 (0.8)
.001
−0.5 (1.1)
.06
Total body BMD, g/cm2
−0.010 (.032)
.18
−0.006 (.026)
.41
Total hip BMD, g/cm2
−0.002 (.032)
.72
0.005 (.014)
.17
Abdominal CT
Total fat, cm2
−75.1 (94.4)§
<.01
−5.2 (72.4)§
.80
Visceral fat, cm2
−38.1 (40.4)§
<.01
−5.5 (26.2)§
.46
Subcutaneous fat, cm2
−37.0 (62.8)
.02
−0.4 (55.9)
.84
Right thigh CT
Total fat, cm2
−18.1 (17.5)
<.01
−5.4 (9.9)
.07
Subcutaneous, cm2
−15.4 (14.8)
<.01
−4.8 (9.5)
.09
Muscle mass, cm2
−2.3 (4.0)§
.03
1.5 (3.7)§
.13
Muscle density, HU
1.3 (1.2)
<.01
0.9 (1.2)
.02
Lean muscle mass, cm2
1.7 (4.0)
.08
2.8 (4.2)
.04
Right quadriceps CT
Muscle mass, cm2
−1.6 (2.4)
.02
−1.4 (3.9)
.31
Muscle density, HU
1.3 (3.7)
<.01
1.0 (1.4)
.03
Lean muscle mass, cm2
−0.17 (2.2)
.54
−0.41 (3.5)
.79
Specific torque, Nm/cm2
−0.24 (0.58)
.11
−0.001 (0.31)
.99
Knee extensor strength
Peak torque, Nm
−16.8 (27.9)
.01
−2.5 (17.2)
.91
Average torque, Nm
−14.0 (22.0)
.01
−3.3 (13.5)
.45
SPPB score
0.7 (1.4)
.04
0.5 (0.9)
.13
#± Standard deviation. §Denotes a significant difference between intervention programs, .