Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat

Table 1

Firing rate response of vagal hepatic afferent fibers before and after intraportal injection of leptin (100 pg. 0.1 mL).

Impulses/5 seconds (mean ± SEM)
No.	Before	30	60	90 minutes
1	54.0±3.1	61.2±1.9	70.6±2.8 *	91.3±6.3^∗
2	73.2±2.2	89.1±3.0^∗	107.3±2.6^∗	122.1±1.2^∗
3	65.2±2.2	113.6±4.1^∗	128.5±2.9^∗	149.8±5.8^∗
4	88.5±2.4	116.9±2.7^∗	106.1±4.0^∗	126.2±3.3^∗
5	74.2±2.7	97.7±2.6^∗	90.8±2.2^∗	86.8±2.9^∗
Mean	71.0±5.7	95.7±10.0^∗	100.7±9.6^∗	115.3±11.7^∗ (𝑛=5, 𝑃<.05)

(*Significant increase, 𝑃<.05).