Relationships of Adrenoceptor Polymorphisms with Obesity

Table 3

Summary of studies showing associations between β3-adrenoceptor polymorphisms and obesity.

Authors [reference]	Year	Population	Subjects	Findings
Clement et al. [83]	1995	French	Patients with morbid obesity	Subjects carrying β3-ADR polymorphisms has an increased capacity to gain weight.
Sakane et al. [84]	1997	Japanese	61 obese women with type 2 diabetes	The Arg64 allele of Trp64Arg may predict difficulty in losing body weight, lowering waist-to-hip ratio, and improving glycemic control and insulin resistance in obese patients with type 2 diabetes.
Umekawa et al. [85]	1999	Japanese	18 omental fat samples obtained during total hysterectomy	Trp64Arg polymorphism was associated with lower lipolytic activities.
Endo et al. [86]	2000	Japanese	553 Japanese schoolchildren (291 boys and 262 girls)	Trp64Arg polymorphism might be a genetic risk factor for obesity in Japanese children.
Oizumi et al. [87]	2001	Japanese	1,685 (935 women and 750 men)	Arg64/Arg64, but not Trp64/Arg64, of the β-adrenergic receptor polymorphism was associated with both obesity and type 2 diabetes in a large Japanese cohort.
Masuo et al. [24]	2005	Japanese	160 nonobese, normotensive men	Trp64Arg polymorphism was related to BP elevations, but not to weight gain in originally nonobese subjects.
Kawaguchi et al. [29]	2006	Japanese	55 overweight/obese men	Trp64Arg polymorphism was related to further weight gain in originally obese subjects.
Gjesing et al. [63]	2007	Danish-Caucasians	7,605	Trp64Arg polymorphism did not confer an increased risk of obesity among Danes, although the variant is associated with type 2 diabetes and quantitative traits related to type 2 diabetes.