Relationships of Adrenoceptor Polymorphisms with Obesity
Table 4
Confounding variables considered to cause the discrepancy of the relationships between β-adrenoceptor polymorphisms and phenotypes of obesity, hypertension, and diabetes.
In lean subjects, β2-AR polymorphisms linked to obesity and obesity-related hypertension, but in obese subjects β2- and β3-AR Polymorphisms related to obesity and obesity-related hypertension. Morbid obesity was linked with β3-AR polymorphisms, but Overweight or mild obesity was not associated with those.
Interaction between β1- and β2-AR polymorphisms with changes in BMI was observed in men only, while in women an interaction between β1- and β3-AR polymorphisms was observed in a longitudinal over a 24-year period large cohort study.