A Model of Insulin Resistance in Mice, Born to Diabetic Pregnancy, Is Associated with Alterations of Transcription-Related Genes in Pancreas and Epididymal Adipose Tissue
Figure 1
(a) Oral glucose-tolerance tests (OGTT). Glycemia during OGTT (3 g/kg-body weight) was measured after a 15-h fast, every 5–10 minutes, for 120 minutes following glucose administration. (b) Intraperitoneal insulin-tolerance tests (IPITT). Glycemia during IPITT (0.5 U/kg body weight) was measured after a 4-h fast, every 5–10 minutes, for 120 minutes following insulin injection. * significant difference between control offspring (open triangle) and hyperglycemic offspring (solid triangle). (c) Evolution of the body weight of the offspring from birth until 3 months of age. Open Square corresponds to control offspring and Solid Square to IR offspring. (d) Glycemia and body weight at 3 months. (e) Serum insulin and insulin mRNA expression in the pancreas. Glycemia, serum insulin, and its mRNA expression were determined as described in Section 2. The offspring were weighed during the study until the age of 3 months. The dams and the offspring after weaning were fed the standard laboratory chow. Values are means SEM, per group of animals. AU: arbitrary units.
