Table 1: Effect of high-fat diet AVE7688, Enalapril or Candoxatril on blood glucose and change in body weight, fat pad and muscle mass.

DeterminationControlControl + AVE7688High FatHigh Fat + AVE7688High Fat + EnalaprilHigh Fat + Candoxatril
(23)(8)(24)(28)(6)(6)

Start Body Weight (g)338 ± 3327 ± 5340 ± 2336 ± 3353 ± 7354 ± 4
End Body Weight (g)485 ± 7454 ± 5560 ± 459 ± 495 ± 1 643 ±
Blood glucose (mg/dL)93 ± 693 ± 796 ± 688 ± 5111 ± 6116 ± 11
Epididymal fat pad (g)5.6 ± 0.44.2 ± 0.212.0 ± 0. 6.5 ± 0. 8.3 ± 1. 17.3 ± 1.
Interscapular Brown fat pad (g)0.38 ± 0.020.34 ± 0.030.68 ± 0.0 0.44 ± 0.0 NDND
Gastrocnemius muscle (g)3.3 ± 0.13.2 ± 0.13.4 ± 0.13.1 ± 0.13.1 ± 0.13.6 ± 0.1

Data are presented as the mean ± SEM. compared to control; compared to high-fat. ND equals not determined. Parentheses indicate the number of experimental animals in each group.