Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity
Table 1
Effect of high-fat diet AVE7688, Enalapril or Candoxatril on blood glucose and change in body weight, fat pad and muscle mass.
Determination
Control
Control + AVE7688
High Fat
High Fat + AVE7688
High Fat + Enalapril
High Fat + Candoxatril
(23)
(8)
(24)
(28)
(6)
(6)
Start Body Weight (g)
338 ± 3
327 ± 5
340 ± 2
336 ± 3
353 ± 7
354 ± 4
End Body Weight (g)
485 ± 7
454 ± 5
560 ±
459 ±
495 ± 1
643 ±
Blood glucose (mg/dL)
93 ± 6
93 ± 7
96 ± 6
88 ± 5
111 ± 6
116 ± 11
Epididymal fat pad (g)
5.6 ± 0.4
4.2 ± 0.2
12.0 ± 0.
6.5 ± 0.
8.3 ± 1.
17.3 ± 1.
Interscapular Brown fat pad (g)
0.38 ± 0.02
0.34 ± 0.03
0.68 ± 0.0
0.44 ± 0.0
ND
ND
Gastrocnemius muscle (g)
3.3 ± 0.1
3.2 ± 0.1
3.4 ± 0.1
3.1 ± 0.1
3.1 ± 0.1
3.6 ± 0.1
Data are presented as the mean ± SEM. compared to control; compared to high-fat. ND equals not determined. Parentheses indicate the number of experimental animals in each group.
