Table 2: Effect of high fat diet AVE7688, Enalapril or Candoxatril on change in serum insulin, leptin, cholesterol, triglycerides, free fatty acids, adiponectin, 8-hydroxy deoxyguanosine, TBARS, and ACE activity.

DeterminationControlHigh FatHigh Fat + AVE7688High Fat + EnalaprilHigh Fat + Candoxatril
(23)(24)(28)(6)(6)

Insulin (ng/mL)1.28 ±.09 0.67 ± 0.0 3.74 ± 1.1
Leptin (pM)446 ± 812052 ± 38 1442 ± 4302852 ± 26
Cholesterol (mg/dL)303 ± 31680 2 347 ± 1 201 ± 2 255 ± 49
Triglycerides (mg/dL)41.8 ± 4.171.5 ± 11.772.0 ± 9.167.3 ± 5.372.2 ± 8.9
Free fatty acids (mmol/L)0.10 ± 0.010.20 ± 0.0 0.21 ± 0.0 0.28 ± 0.0 0.20 ± 0.04
Adiponectin (μg/mL)7.9 ± 0.611.0 ± 0. 9.5 ± 0.57.7 ± 0.77.8 ± 0.7
8-OH DG (ng/mL)1.88 ± 0.102.58 ± 0.1 1.91 ± 0.1 1.85 ± 0.091.88 ± 0.14
TBARS ( g/mL)0.13 ± 0.010.50 ± 0.0 0.26 ± 0.0 0.71 ± 0.0 0.55 ± 0.0
ACE activity (mU/mL/min)94 ± 875 ± 623 ± 4 ± 111 ± 14

Data are presented as the mean ± SEM. compared to control; compared to high-fat. ND equals not determined. Parentheses indicate the number of experimental animals in each group.