Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity

Table 2

Effect of high fat diet ± AVE7688, Enalapril or Candoxatril on change in serum insulin, leptin, cholesterol, triglycerides, free fatty acids, adiponectin, 8-hydroxy deoxyguanosine, TBARS, and ACE activity.

Determination	Control	High Fat	High Fat + AVE7688	High Fat + Enalapril	High Fat + Candoxatril
	(23)	(24)	(28)	(6)	(6)
Insulin (ng/mL)	1.28 ±.09	3.60±0.43^a	1.78±0.17^b	0.67 ± 0.05^b	3.74 ± 1.19^a
Leptin (pM)	446 ± 81	2052 ± 389^a	592±75^b	1442 ± 430	2852 ± 260^a
Cholesterol (mg/dL)	303 ± 31	680 ± 29^a	347 ± 15^b	201 ± 22^b	255 ± 49
Triglycerides (mg/dL)	41.8 ± 4.1	71.5 ± 11.7	72.0 ± 9.1	67.3 ± 5.3	72.2 ± 8.9
Free fatty acids (mmol/L)	0.10 ± 0.01	0.20 ± 0.03^a	0.21 ± 0.02^a	0.28 ± 0.04^a	0.20 ± 0.04
Adiponectin (μg/mL)	7.9 ± 0.6	11.0 ± 0.7^a	9.5 ± 0.5	7.7 ± 0.7	7.8 ± 0.7
8-OH DG (ng/mL)	1.88 ± 0.10	2.58 ± 0.17^a	1.91 ± 0.17^b	1.85 ± 0.09	1.88 ± 0.14
TBARS (𝜇g/mL)	0.13 ± 0.01	0.50 ± 0.07^a	0.26 ± 0.05^b	0.71 ± 0.03^a	0.55 ± 0.02^a
ACE activity (mU/mL/min)	94 ± 8	75 ± 6	23 ± 2^a,b	4 ± 1^a,b	111 ± 14

Data are presented as the mean ± SEM. ^a𝑃<.05 compared to control; ^b𝑃<.05 compared to high-fat. ND equals not determined. Parentheses indicate the number of experimental animals in each group.