Clinical Study

Influence of Sleeve Gastrectomy on NASH and Type 2 Diabetes Mellitus

Table 3

Separate consideration of clinical and biological data at 1- and 3-year followup for patients with NASH and normal liver histology.

VariableBefore surgery1 year after surgery3 years after surgeryP valueP difference
Normal liverNASHNormal liverNASHNormal liverNASHNormal liverNASH

BMI kg/m244.2 ± 5.645.9 ± 8.328.2 ± 4.930.8 ± 8.830.3 ± 5.630.8 ± 5.3<.0001<.0001<.05
HbA1c %5.4 ± 0.56.1 ± 1.45.2 ± 0.45.4 ± 0.44.9 ± 0.45.2 ± 0.5NS<.01<.001
AST level U/L17.9 ± 4.827.9 ± 14.418 ± 11.219.2 ± 9.319.2 ± 11.017.2 ± 2.4NS<.01NS
ALT level U/L23.9 ± 9.142.1 ± 25.325.8 ± 27.317.5 ± 7.322.0 ± 16.112.2 ± 1.9NS<.0001NS
Triglyceride level mmol/l1.4 ± 0.71.8 ± 1.40.9 ± 0.31.0 ± 0.30.8 ± 0.30.9 ± 0.4<.05<.0001<.05
Cholesterol level mmol/L5.3 ± 0.85.0 ± 1.05.7 ± 1.55.0 ± 0.84.8 ± 1.15.2 ± 0.9NSNSNS
LDL level mmol/L3.3 ± 0.73.0 ± 0.83.6 ± 0.93.1 ± 0.82.7 ± 1.13.3 ± 0.7NSNSNS
HDL level mmol/L1.4 ± 0.41.2 ± 0.41.7 ± 0.71.5 ± 0.31.5 ± 0.51.5 ± 0.3NS<.0001NS

Figures presented as mean ± standard deviation; separate P values for NASH and normal liver histology were determined with Kruskal-Wallis test, P difference determined with two-way ANOVA.