Influence of Sleeve Gastrectomy on NASH and Type 2 Diabetes Mellitus
Table 3
Separate consideration of clinical and biological data at 1- and 3-year followup for patients with NASH and normal liver histology.
Variable
Before surgery
1 year after surgery
3 years after surgery
P value
P difference
Normal liver
NASH
Normal liver
NASH
Normal liver
NASH
Normal liver
NASH
BMI kg/m2
44.2 ± 5.6
45.9 ± 8.3
28.2 ± 4.9
30.8 ± 8.8
30.3 ± 5.6
30.8 ± 5.3
<.0001
<.0001
<.05
HbA1c %
5.4 ± 0.5
6.1 ± 1.4
5.2 ± 0.4
5.4 ± 0.4
4.9 ± 0.4
5.2 ± 0.5
NS
<.01
<.001
AST level U/L
17.9 ± 4.8
27.9 ± 14.4
18 ± 11.2
19.2 ± 9.3
19.2 ± 11.0
17.2 ± 2.4
NS
<.01
NS
ALT level U/L
23.9 ± 9.1
42.1 ± 25.3
25.8 ± 27.3
17.5 ± 7.3
22.0 ± 16.1
12.2 ± 1.9
NS
<.0001
NS
Triglyceride level mmol/l
1.4 ± 0.7
1.8 ± 1.4
0.9 ± 0.3
1.0 ± 0.3
0.8 ± 0.3
0.9 ± 0.4
<.05
<.0001
<.05
Cholesterol level mmol/L
5.3 ± 0.8
5.0 ± 1.0
5.7 ± 1.5
5.0 ± 0.8
4.8 ± 1.1
5.2 ± 0.9
NS
NS
NS
LDL level mmol/L
3.3 ± 0.7
3.0 ± 0.8
3.6 ± 0.9
3.1 ± 0.8
2.7 ± 1.1
3.3 ± 0.7
NS
NS
NS
HDL level mmol/L
1.4 ± 0.4
1.2 ± 0.4
1.7 ± 0.7
1.5 ± 0.3
1.5 ± 0.5
1.5 ± 0.3
NS
<.0001
NS
Figures presented as mean ± standard deviation; separate P values for NASH and normal liver histology were determined with Kruskal-Wallis test, P difference determined with two-way ANOVA.