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Journal of Obesity
Volume 2011 (2011), Article ID 946795, 7 pages
http://dx.doi.org/10.1155/2011/946795
Research Article

Serum Neopterin Is Not Increased in Obese Juveniles

1Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
2Department of Pediatrics, University Hospital of Salzburg, 5020 Salzburg, Austria
3Division of Biological Chemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria

Received 11 June 2010; Accepted 22 December 2010

Academic Editor: A. Halpern

Copyright © 2011 Harald Mangge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Cardiovascular disease is associated with inflammation and immune activation, concentrations of immune activation markers like neopterin predict outcome in adults. Methods. Serum neopterin concentrations and early metabolic and pre-atherosclerotic symptoms were analyzed in 295 obese juveniles and 101 normal weight controls of similar age. Additionally, the influence of a 12 months weight reduction program on neopterin levels was investigated in 31 obese juveniles. Results. Intima-media thickness of common carotid arteries (IMT) and the concentrations of C-reactive protein (CRP) were increased in the obese juveniles ( 𝑃 < . 0 0 1 ). Also triglycerides, oxidized LDL, fasted insulin levels, HOMA-index, leptin, liver transaminases and uric acid were increased compared to the controls. However, serum neopterin was decreased in the obese versus non-obese juveniles ( 𝑃 < . 0 3 ). The intervention consisting of regular sports, nutritional devices, and a psychologic attendance led after 12 months to an increase of neopterin concentration ( 𝑃 < . 0 5 ; paired test). Conclusions. Neopterin concentrations in juvenile obesity behaved considerably different from what was demonstrated in adults, levels did not correlate with metabolic and pre-atherosclerotic symptoms found in early phases although early vascular burden and chronic low grade inflammation was indicated by increased IMT and CRP. Neopterin concentrations increased after a 12 months intervention program.