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Journal of Obesity
Volume 2012 (2012), Article ID 102942, 8 pages
Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study
1Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
2Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
3Alzheimer’s Disease Center at Boston university, Boston, MA 02215, USA
4Department of Health Sciences, Northeastern University, Boston, MA 02115, USA
Received 12 September 2012; Revised 6 November 2012; Accepted 27 November 2012
Academic Editor: David Allison
Copyright © 2012 Xian-Yong Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- N. A. Christakis and J. H. Fowler, “The spread of obesity in a large social network over 32 years,” The New England Journal of Medicine, vol. 357, no. 4, pp. 370–379, 2007.
- H. H. M. Maes, M. C. Neale, and L. J. Eaves, “Genetic and environmental factors in relative body weight and human adiposity,” Behavior Genetics, vol. 27, no. 4, pp. 325–351, 1997.
- P. Monteleone, A. Tortorella, V. Martiadis, C. Serritella, A. Fuschino, and M. Maj, “Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity,” Psychosomatic Medicine, vol. 66, no. 5, pp. 744–748, 2004.
- A. H. El-Gharbawy, D. C. Adler-Wailes, M. C. Mirch et al., “Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 9, pp. 3548–3552, 2006.
- W. Lyons, L. A. Mamounas, G. A. Ricaurte et al., “Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 26, pp. 15239–15244, 1999.
- M. Rios, G. Fan, C. Fekete et al., “Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity,” Molecular Endocrinology, vol. 15, no. 10, pp. 1748–1757, 2001.
- L. Cao, E. Y. Choi, X. L. Liu, et al., “White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic—adipocyte axis,” Cell Metabolism, vol. 14, pp. 324–338, 2011.
- K. S. Krabbe, A. R. Nielsen, R. Krogh-Madsen, et al., “Brain derived neurotrophic factor (BDNF) and type 2 diabetes,” Diabetologia, vol. 50, pp. 431–438, 2007.
- G. S. H. Yeo, C. C. C. Hung, J. Rochford et al., “A de novo mutation affecting human TrkB associated with severe obesity and developmental delay,” Nature Neuroscience, vol. 7, no. 11, pp. 1187–1189, 2004.
- Y. Yu, Q. Wang, and X. F. Huang, “Energy-restricted pair-feeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice,” Neuroscience, vol. 160, no. 2, pp. 295–306, 2009.
- S. Friedel, F. F. Horro, A. K. Wermter et al., “Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder,” American Journal of Medical Genetics, vol. 132, no. 1, pp. 96–99, 2005.
- M. Ribasés, M. Gratacòs, F. Fernández-Aranda, et al., “Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations,” Human Molecular Genetics, vol. 13, pp. 1205–1212, 2004.
- S. Beckers, A. Peeters, D. Zegers, I. Mertens, L. V. Gaal, and W. Van Hul, “Association of the BDNF Val66Met variation with obesity in women,” Molecular Genetics and Metabolism, vol. 95, no. 1-2, pp. 110–112, 2008.
- J. Gunstad, P. Schofield, R. H. Paul et al., “BDNF Val66Met polymorphism is associated with body mass index in healthy adults,” Neuropsychobiology, vol. 53, no. 3, pp. 153–156, 2006.
- J. Zhao, J. P. Bradfield, M. Li et al., “The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI,” Obesity, vol. 17, no. 12, pp. 2254–2257, 2009.
- Z. Y. Chen, P. D. Patel, G. Sant et al., “Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons,” Journal of Neuroscience, vol. 24, no. 18, pp. 4401–4411, 2004.
- M. F. Egan, M. Kojima, J. H. Callicott et al., “The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function,” Cell, vol. 112, no. 2, pp. 257–269, 2003.
- K. L. Tucker, “Stress and nutrition in relation to excess development of chronic disease in Puerto Rican adults living in the Northeastern USA,” Journal of Medical Investigation, vol. 52, pp. 252–258, 2005.
- C. Q. Lai, K. L. Tucker, L. D. Parnell et al., “PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases the boston puerto rican health study,” Diabetes, vol. 57, no. 4, pp. 809–816, 2008.
- K. L. Tucker, L. A. Bianchi, J. Maras, and O. I. Bermudez, “Adaptation of a food frequency questionnaire to assess diets of Puerto Rican and non-Hispanic adults,” American Journal of Epidemiology, vol. 148, no. 5, pp. 507–518, 1998.
- K. L. Tucker, J. Mattei, S. E. Noel et al., “The Boston Puerto Rican health study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities,” BMC Public Health, vol. 10, article 107, 2010.
- C. Q. Lai, K. L. Tucker, S. Choudhry et al., “Population admixture associated with disease prevalence in the Boston Puerto Rican health study,” Human Genetics, vol. 125, no. 2, pp. 199–209, 2009.
- J. Li and L. Ji, “Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix,” Heredity, vol. 95, no. 3, pp. 221–227, 2005.
- P. C. Maisonpierre, L. Belluscio, B. Friedman et al., “NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression,” Neuron, vol. 5, no. 4, pp. 501–509, 1990.
- S. G. Kernie, D. J. Liebl, and L. F. Parada, “BDNF regulates eating behavior and locomotor activity in mice,” The EMBO Journal, vol. 19, no. 6, pp. 1290–1300, 2000.
- B. K. Pedersen, M. Pedersen, K. S. Krabbe, H. Bruunsgaard, V. B. Matthews, and M. A. Febbraio, “Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals,” Experimental Physiology, vol. 94, no. 12, pp. 1153–1160, 2009.
- X. Y. Zhang, D. F. Zhou, G. Y. Wu et al., “BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia,” Neuropsychopharmacology, vol. 33, no. 9, pp. 2200–2205, 2008.
- K. Akkermann, K. Hiio, I. Villa, and J. Harro, “Food restriction leads to binge eating dependent upon the effect of the brain-derived neurotrophic factor Val66Met polymorphism,” Psychiatry Research, vol. 185, no. 1-2, pp. 39–43, 2011.
- Y. Y. Shugart, L. Chen, I. N. M. Day et al., “Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI,” European Journal of Human Genetics, vol. 17, no. 8, pp. 1050–1055, 2009.
- V. Arija, M. Ferrer-Barcala, N. Aranda, and J. Canals, “BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders,” BMC Public Health, vol. 10, article 363, 2010.
- I. van Oostrom, B. Franke, M. Rijpkema, et al., “Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women,” Biological Psychology, vol. 89, no. 1, pp. 214–219, 2012.
- M. Ono, Y. Itakura, T. Nonomura et al., “Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice,” Metabolism, vol. 49, no. 1, pp. 129–133, 2000.
- J. R. Tonra, M. Ono, X. Liu et al., “Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-/ mice,” Diabetes, vol. 48, no. 3, pp. 588–594, 1999.
- M. A. Pelleymounter, M. J. Cullen, and C. L. Wellman, “Characteristics of BDNF-induced weight loss,” Experimental Neurology, vol. 131, no. 2, pp. 229–238, 1995.
- B. Xu, E. H. Goulding, K. Zang et al., “Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor,” Nature Neuroscience, vol. 6, no. 7, pp. 736–742, 2003.
- S. I. Rapoport, J. S. Rao, and M. Igarashi, “Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 77, no. 5-6, pp. 251–261, 2007.
- A. Vines, A. M. Delattre, M. M. Lima, et al., “The role of 5-HT1A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism,” Neuropharmacology, vol. 62, no. 1, pp. 184–191, 2012.