Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice
Figure 3
Plasma glucose concentration curve during intraperitoneal glucose tolerance test (IPGTT) for C57Bl/6J mice fed a normal or high-fat-containing diet for 24 weeks and the high-fat diet with or without ilepatril, candoxatril, or enalapril for the last 12 weeks (intervention protocol). Data are the mean ± SEM in mM. Fasting basal blood glucose levels were , , , , and mg/dL for control, high fat, high fat + ilepatril, high fat + candoxatril, and high fat + enalapril, respectively. Control (closed circles), high fat (open circles), high fat + ilepatril (closed innervated triangle), high fat + candoxatril (open triangle), and high fat + enalapril (closed rectangle). The area under the curve (AUC) was significantly different for high-fat-fed mice versus control and high-fat-fed mice treated with ilepatril versus control. There was no significant difference for AUC between mice fed a high-fat diet containing candoxatril or enalapril versus control. The number of mice in each group was the same as shown in Table 2.
