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| From birth to 3 years | From 3 to 10 years | From 10 to 18 years | Adult |
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Axiological evaluation | 3-4 months | 6 months | 6–12 months | |
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Nutritionist/dietician evaluation | 6–12 months | 6–12 months | 6–12 months | 6–12 months |
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Blood sample (OGTT, HbA1c, total cholesterol and HDL, triglyceride level, uricemia, TSH, fT4, IGF1) | 6 month | 6–12 months | 6–12 months | 1 year |
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Evaluation of pubertal development (dosage of LH, FSH, estradiol (in females) and testosterone (in males) both basal and after GnRH) | | | According to clinical evaluation | |
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Bone age (left hand X-ray) | | GH therapy: 1 year | According to clinical evaluation | |
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Evaluation of bone density | | | | |
Blood sample for Ca, P and Mg, protidemia, PTH, vitamin D3. | | 1-2 years | 1-2 years | 1-2 years |
DEXA | | 1-2 years | 1-2 years | 1-2 years |
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Polysomnography | No GH therapy: 1 year GH therapy: 3–6 months | 1 year | 1 year | In case of problem |
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ENT with fibroscopy | No GH therapy: 6–12 months GH therapy: 3–6 months | In case of problem | In case of problem | |
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Orthopedic evaluation | 1 year (consider the necessity of spine X-ray) | 6 months (consider the necessity of spine X-ray) | 6 months (consider the necessity of spine X-ray) | In case of problem |
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Orthoptic/ophthalmology evaluation | 1 year | In case of problem | In case of problem | |
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Dental evaluation | Annual after 2 years | 6 months | 6 months | In case of problem |
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Dermatological evaluation | | In case of skin picking | In case of skin picking | In case of skin picking |
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Echocardiography and cardiological evaluation | | | | 2 years |
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Neuropsychiatric and physiatric evaluation | 3 months | 1 year | 1 year | 1-2 years |
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