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Journal of Obesity
Volume 2012 (2012), Article ID 505274, 9 pages
http://dx.doi.org/10.1155/2012/505274
Review Article

Obesity and Pulmonary Hypertension: A Review of Pathophysiologic Mechanisms

1Section of Cardiology, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
2Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA

Received 3 March 2012; Accepted 18 July 2012

Academic Editor: David Allison

Copyright © 2012 Scott E. Friedman and Bruce W. Andrus. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pulmonary hypertension (PH) is a potentially life-threatening condition arising from a wide variety of pathophysiologic mechanisms. Effective treatment requires a systematic diagnostic approach to identify all reversible mechanisms. Many of these mechanisms are relevant to those afflicted with obesity. The unique mechanisms of PH in the obese include obstructive sleep apnea, obesity hypoventilation syndrome, anorexigen use, cardiomyopathy of obesity, and pulmonary thromboembolic disease. Novel mechanisms of PH in the obese include endothelial dysfunction and hyperuricemia. A wide range of effective therapies exist to mitigate the disability of PH in the obese.