Influence of Weight Loss, Body Composition, and Lifestyle Behaviors on Plasma Adipokines: A Randomized Weight Loss Trial in Older Men and Women with Symptomatic Knee Osteoarthritis
Table 3
Plasma concentrations of adipokines at baseline and 6 months. Statistical analysis was performed on 6 months log values. These means are estimated marginal means (SEM). Nontransformed values are presented for ease of reference.
Weight stable
Weight loss
95% confidence interval {cutoff for 50% power} for mean difference (WL − WS) at 6 months
Men
Women
Men
Women
Men
Women
()
()
()
()
Log leptin, ng/mL
Baseline
1.53 (0.08)
1.87 (0.08)
1.37 (0.09)
1.81 (0.08)
6 months
1.37 (0.09)
1.88 (0.06)
1.30 (0.10)
1.74 (0.05)
(−0.37, 0.20)
(−0.31, 0.02)
{±0.29}
{±0.17}
Leptin, ng/mL
Baseline
39.72 (7.33)
86.53 (12.86)
26.54 (3.64)
77.16 (12.17)
6 months
34.86 (7.16)
91.80 (12.71)
19.10 (2.14)
63.90 (12.69)
Log soluble leptin receptor, ng/mL
Baseline
1.35 (0.02)
1.47 (0.04)
1.34 (0.02)
1.43 (0.04)
6 months
1.31 (0.05)
1.53 (0.03)
1.40 (0.06)
1.49 (0.03)
(−0.06, 0.25)
(−0.14, 0.05)
{±0.16}
{±0.10}
Soluble leptin receptor, ng/mL
Baseline
22.70 (1.02)
30.44 (3.41)
22.10 (0.71)
28.68 (2.27)
6 months
21.99 (1.86)
35.04 (2.68)
24.82 (1.36)
31.01 (2.08)
Log adiponectin, mg/mL
Baseline
3.99 (0.06)
4.15 (0.06)
4.05 (0.07)
4.17 (0.05)
6 months
4.02 (0.04)
4.12 (0.05)
4.04 (0.04)
4.25 (0.05)
(−0.10, 0.14)
(−0.03, 0.29)
{±0.12}
{±0.16}
Adiponectin, mg/mL
Baseline
11.41 (1.66)
15.08 (2.12)
12.13 (1.61)
16.60 (1.87)
6 months
11.52 (1.51)
14.82 (1.67)
13.13 (1.90)
18.06 (1.70)
Log-free leptin index
Baseline
2.18 (0.09)
2.41 (0.10)
2.02 (0.10)
2.38 (0.10)
6 months
2.06 (0.12)
2.37 (0.06)
1.90 (0.13)
2.24 (0.05)
(−0.53, 0.22)
(−0.29, 0.04)
{±0.38}
{±0.17}
Free leptin index
Baseline
177.26 (33.67)
349.62 (75.91)
125.74 (18.89)
294.41 (51.15)
6 months
276.27 (150.28)
272.86 (36.60)
76.45 (6.65)
213.85 (42.74)
Log leptin : adiponectin ratio
Baseline
0.54 (0.11)
0.73 (0.10)
0.32 (0.12)
0.65 (0.10)
6 months
0.37 (0.09)
0.78 (0.08)
0.24 (0.10)
0.48 (0.08)
(−0.44, 0.17)
(−0.54, −0.05)*
{±0.31}
{±0.25}
Leptin : adiponectin ratio
Baseline
4.12 (0.74)
7.53 (1.76)
2.82 (0.51)
5.42 (0.96)
6 months
3.38 (0.64)
6.73 (0.91)
1.78 (0.30)
4.23 (1.05)
Log leptin/kg body fat
Baseline
−0.02 (0.07)
0.25 (0.08)
−0.28 (0.08)
0.18 (0.08)
6 months
−0.16 (0.10)
0.24 (0.04)
−0.30 (0.12)
0.21 (0.04)
(−0.50, 0.21)
(−0.16, 0.09)
{±0.36}
{±0.13}
Leptin/kg body fat
Baseline
0.97 (0.13)
2.06 (0.30)
0.69 (0.10)
1.77 (0.28)
6 months
0.83 (0.14)
2.12 (0.29)
0.62 (0.07)
1.57 (0.20)
Free leptin index = (leptin : soluble leptin receptor) × 100.
*Indicates for comparison between groups within gender. (Note that corresponds to the associated difference confidence interval not overlapping 0.00.) Indicates to <0.100 for comparison between groups within gender. The power is 50% if the absolute value of the true mean difference equals the half width of the respective 95% confidence interval.
