Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women

Table 2

Odds ratios (ORs) of colon cancer for BMI by age, decades^a.

		All postmenopausal women				Postmenopausal women with no HRT				Postmenopausal women with HRT
		Case/control	OR	𝑃	𝑃^∗	Case/control	OR	𝑃	𝑃^∗
	Normal^c (ref)	147/315	1.00	—		72/105	1.00	—		75/210	1.00	—
BMI 2 yrs^b	Overweight	159/302	0.98 (0.73–1.32)	0.88		87/117	0.95 (0.60–1.49)	0.82		72/185	1.01 (0.67–1.52)	0.96
	Obese	188/279	1.25 (0.92–1.69)	0.16	0.19	120/123	1.39 (0.89–2.17)	0.15	0.11	68/156	1.21 (0.78–1.87)	0.39	0.57
	Normal (ref)	192/410	1.00	—		101/145	1.00	—		91/265	1.00	—
BMI 50s	Overweight	125/242	0.96 (0.74–1.32)	0.77		73/91	1.06 (0.68–1.65)	0.79		52/151	0.95 (0.58–1.40)	0.66
	Obese	126/163	1.27 (0.97–1.92)	0.07	0.19	70/79	1.18 (0.72–1.93)	0.50	0.64	56/84	1.74 (1.08–2.80)	0.02	0.08
	Normal (ref)	250/529	1.00	—		127/192	1.00	—		123/337	1.00	—
BMI 40s	Overweight	101/176	1.07 (0.78–1.47)	0.66		57/64	1.29 (0.80–2.07)	0.30		44/112	1.01 (0.65–1.59)	0.93
	Obese	71/114	1.25 (0.85–1.82)	0.26	0.43	43/59	1.18 (0.69–2.00)	0.54	0.81	28/55	1.45 (0.82–2.57)	0.20	0.25
	Normal (ref)	306/629	1.00	—		159/227	1.00	—		147/402	1.00	—
BMI 30s	Overweight	66/115	1.06 (0.74–1.52)	0.76		37/52	1.02 (0.60–1.72)	0.95		29/63	1.11 (0.65–1.87)	0.71
	Obese	42/56	1.42 (0.90–2.27)	0.13	0.90	27/27	1.50 (0.80–2.83)	0.21	0.47	15/29	1.38 (0.68–2.83)	0.38	0.76
	Normal (ref)	333/650	1.00	—		178/250	1.00	—		153/400	1.00	—
BMI 20s	Overweight	48/74	1.15 (0.76–1.75)	0.50		29/30	1.32 (0.73–2.40)	0.35		19/44	1.10 (0.60–2.02)	0.77
	Obese	18/36	0.87 (0.47–1.63)	0.67	0.50	13/20	0.85 (0.38–1.87)	0.68	0.20	5/16	0.91 (0.31–2.65)	0.86	0.93

^aAdjusted for age, race, gender, education, income, physical activity, smoking, alcohol, nonsteroidal anti-inflammatory drugs use, family history of colorectal cancer, age at menarche, and parity. ^b2 years before recruitment/interview. ^cNormal: ≥18.5 to <25 kg/m²; overweight: ≥25 to <30 kg/m²; obese: ≥30 kg/m². ^*𝑃 value for trend.