Table 2: Summary of PTP1B-deficient genetic mouse models and their associated metabolic phenotypes. ND: not determined.

PTP1B-deficient mouse modelBody weight/adiposity phenotypeLeptin sensitivityGlucose homeostasisReferences

Global
(whole body)
DecreasedIncreasedImproved GTT
Improved ITT
[3, 4]
Brain specific
(Nestin-Cre)
DecreasedIncreasedImproved GTT
Improved ITT
[45]
POMC-neuron specific
(POMC-Cre)
DecreasedIncreasedImproved GTT
Improved ITT
[46]
Adipose/macrophage specific
(aP2-Cre)
IncreasedNDND[45]
Muscle specific
(MCK-Cre)
No changeNDImproved GTT
Improved ITT
[48]
Liver specific
(Albumin-Cre)
No changeNDImproved GTT[49]
Adipocyte specific
(adiponectin-Cre)
No change in body weight
Increased adipocyte size
DecreasedMild glucose intolerance[50]
LepRb specific
(LepRb-Cre)
DecreasedIncreasedImproved GTTUnpublished (Tsou and Bence)