The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency

Table 2

Summary of PTP1B-deficient genetic mouse models and their associated metabolic phenotypes. ND: not determined.

PTP1B-deficient mouse model	Body weight/adiposity phenotype	Leptin sensitivity	Glucose homeostasis	References
Global; (whole body)	Decreased	Increased	Improved GTT; Improved ITT	[3, 4]
Brain specific; (Nestin-Cre)	Decreased	Increased	Improved GTT; Improved ITT	[45]
POMC-neuron specific; (POMC-Cre)	Decreased	Increased	Improved GTT; Improved ITT	[46]
Adipose/macrophage specific; (aP2-Cre)	Increased	ND	ND	[45]
Muscle specific; (MCK-Cre)	No change	ND	Improved GTT; Improved ITT	[48]
Liver specific; (Albumin-Cre)	No change	ND	Improved GTT	[49]
Adipocyte specific; (adiponectin-Cre)	No change in body weight; Increased adipocyte size	Decreased	Mild glucose intolerance	[50]
LepRb specific; (LepRb-Cre)	Decreased	Increased	Improved GTT	Unpublished (Tsou and Bence)