About this Journal Submit a Manuscript Table of Contents
Journal of Obesity
Volume 2013 (2013), Article ID 291546, 11 pages
http://dx.doi.org/10.1155/2013/291546
Review Article

Obesity as a Major Risk Factor for Cancer

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Oncology, University of Bari “Aldo Moro”, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy

Received 18 December 2012; Revised 17 July 2013; Accepted 25 July 2013

Academic Editor: Francesco Saverio Papadia

Copyright © 2013 Giovanni De Pergola and Franco Silvestris. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [57 citations]

The following is the list of published articles that have cited the current article.

  • Mauro Zamboni, Andrea P. Rossi, Francesco Fantin, Giulia Zamboni, Salvatore Chirumbolo, Elena Zoico, and Gloria Mazzali, “Adipose tissue, diet and aging,” Mechanisms of Ageing and Development, 2013. View at Publisher · View at Google Scholar
  • Mervi T. Hyvönen, and Kirsty L. Spalding, “Maintenance of white adipose tissue in man,” The International Journal of Biochemistry & Cell Biology, 2014. View at Publisher · View at Google Scholar
  • Hichem Bouguerra, Hajer Guissouma, Soumaya Labidi, Nejla Stambouli, Raja Marrakchi, Salem Chouaib, Amel Ben Ammar Elgaaied, Hammouda Boussen, and Asma Gati, “Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 16, pp. 6805–6810, 2014. View at Publisher · View at Google Scholar
  • Aytekin Tokmak, Mahmut Kuntay Kokanali, Ali Irfan Guzel, Aydan Kara, Hasan Onur Topcu, and Sabri Cavkaytar, “Polycystic Ovary Syndrome and Risk of Endometrial Cancer: a Mini-Review,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 17, pp. 7011–7014, 2014. View at Publisher · View at Google Scholar
  • Weiqiang Zhou, Yuwang Tian, Hangjun Gong, Shanchun Guo, and Chengyu Luo, “Oncogenic role and therapeutic target of leptin signaling in colorectal cancer,” Expert Opinion on Therapeutic Targets, vol. 18, no. 8, pp. 961–971, 2014. View at Publisher · View at Google Scholar
  • Ali Serdar Gözen, Yigit Akin, Ender Özden, Mutlu Ates, Marcel Hruza, and Jens Rassweiler, “Impact of body mass index on outcomes of laparoscopic radical prostatectomy with long-term follow-up,” Scandinavian Journal of Urology, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  • Anna M. Zawadzka, Birgit Schilling, Jason M. Held, Alexandria K. Sahu, Michael P. Cusack, Penelope M. Drake, Susan J. Fisher, and Bradford W. Gibson, “Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition,” Electrophoresis, 2014. View at Publisher · View at Google Scholar
  • Scott Weichenthal, Jane A. Hoppin, and Francois Reeves, “Obesity and the Cardiovascular Health Effects of Fine Particulate Air Pollution,” Obesity, vol. 22, no. 7, pp. 1580–1589, 2014. View at Publisher · View at Google Scholar
  • Eun Jung Jang, Hyo Kyeong Kim, Hana Jeong, Ye Seul Lee, Mi Gyeong Jeong, Su Jung Bae, Sanghee Kim, Sang Kook Lee, and Eun Sook Hwang, “Anti-Adipogenic Activity of the Naturally Occurring Phenanthroindolizidine Alkaloid Antofine via Direct Suppression of PPAR gamma Expression,” Chemistry & Biodiversity, vol. 11, no. 6, pp. 962–969, 2014. View at Publisher · View at Google Scholar
  • Grzegorz Słomian, Elżbieta Świętochowska, Jolanta Malinowska-Borowska, Sławomir Kasperczyk, Anna Rogalska, and Przemysław Nowak, “Association between chemotherapy and plasma adipokines in patients with colorectal cancer,” Pharmacological Reports, 2014. View at Publisher · View at Google Scholar
  • Matthew G. K. Benesch, Xiaoyun Tang, Tatsuo Maeda, Akira Ohhata, Yuan Y. Zhao, Bernard P. C. Kok, Jay Dewald, Mary Hitt, Jonathan M. Curtis, Todd P. W. McMullen, and David N. Brindley, “Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice,” Faseb Journal, vol. 28, no. 6, pp. 2655–2666, 2014. View at Publisher · View at Google Scholar
  • Ana I. Pérez-Hernández, Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, and Gema Frühbeck, “Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion,” Frontiers in Endocrinology, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Hyojung Paik, Hyoung-Sam Heo, Hyo-jeong Ban, and Seong Beom Cho, “Unraveling human protein interaction networks underlying co-occurrences of diseases and pathological conditions,” Journal of Translational Medicine, vol. 12, 2014. View at Publisher · View at Google Scholar
  • Fei Li, Changtao Jiang, Michele C. Larsen, Justin Bushkofsky, Kristopher W. Krausz, Ting Wang, Colin R. Jefcoate, and Frank J. Gonzalez, “Lipidomics Reveals a Link between CYP1B1 and SCD1 in Promoting Obesity,” Journal of Proteome Research, pp. 140410142049008, 2014. View at Publisher · View at Google Scholar
  • Monica Colitti, and Stefano Grasso, “Nutraceuticals and regulation of adipocyte life: Premises or promises,” BioFactors, 2014. View at Publisher · View at Google Scholar
  • Chelsea Catsburg, Victoria A. Kirsh, Colin L. Soskolne, Nancy Kreiger, Erin Bruce, Thi Ho, Scott T. Leatherdale, and Thomas E. Rohan, “Associations between anthropometric characteristics, physical activity, and breast cancer risk in a Canadian cohort,” Breast Cancer Research and Treatment, 2014. View at Publisher · View at Google Scholar
  • L. Zelek, and J. -P. Spano, “Obésité et cancers : de la prévention primaire à la prévention tertiaire,” Obésité, 2014. View at Publisher · View at Google Scholar
  • Ugur Uyeturk, Hasmet Sarıcı, Buket Kın Tekce, Muzaffer Eroglu, Eray Kemahlı, Ummugul Uyeturk, and Adnan Gucuk, “Serum omentin level in patients with prostate cancer,” Medical Oncology, vol. 31, no. 4, 2014. View at Publisher · View at Google Scholar
  • Socrates Villegas-Comonfort, Rocio Castillo-Sanchez, Nathalia Serna-Marquez, Pedro Cortes-Reynosa, and Eduardo Perez Salazar, “Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells,” Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2014. View at Publisher · View at Google Scholar
  • Matthew GK Benesch, Yi M Ko, Todd PW McMullen, and David N Brindley, “Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions,” FEBS Letters, 2014. View at Publisher · View at Google Scholar
  • Miao Qin, Lan-Qing Ma, Juan Tan, Ya-Rong Chen, Liang-Ru Zhu, Rong Lin, Wei-Ling Hu, Jing-Nan Li, Kun-He Zhang, Yan Wang, Jian-Sheng Li, Bing Xiao, Hao-Yan Chen, Ying-Xuan Chen, and Jing-Yuan Fang, “Risk factors for colorectal neoplasms based on colonoscopy and pathological diagnoses of Chinese citizens: a multicenter, case-control study,” International Journal of Colorectal Disease, 2014. View at Publisher · View at Google Scholar
  • Ethan Bortniker, and Joseph C. Anderson, “Do Recent Epidemiologic Observations Impact Who and How We Should Screen for CRC?,” Digestive Diseases and Sciences, 2014. View at Publisher · View at Google Scholar
  • Jason F. Ohlstein, Amy L. Strong, John A. McLachlan, Jeffrey M. Gimble, Matthew E. Burow, and Bruce A. Bunnell, “Bisphenol A enhances adipogenic differentiation of human adipose stromal/stem cells,” Journal Of Molecular Endocrinology, vol. 53, no. 3, pp. 345–353, 2014. View at Publisher · View at Google Scholar
  • Juan Carlos Souto, Georgia Pena, Andrey Ziyatdinov, Alfonso Buil, Sonia Lopez, Jordi Fontcuberta, and Jose Manuel Soria, “A genomewide study of body mass index and its genetic correlation with thromboembolic risk,” Thrombosis and Haemostasis, vol. 112, no. 5, pp. 1036–1043, 2014. View at Publisher · View at Google Scholar
  • Su-Chen Lee, Shih-Meng Tsai, Ming-Feng Hou, Li-Ying Tien, Szu-Hsien Wu, Lisa Ann Hou, Joseph M Tsai, and Li-Yu Tsai, “Increased Igf-I/Igfbp-3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case-Control Study,” Journal of Clinical Laboratory Analysis, 2014. View at Publisher · View at Google Scholar
  • M.-F. Avril, P. Bahadoran, O. Cabaret, O. Caron, A. de la Fouchardière, F. Demenais, L. Desjardins, T. Frébourg, P. Hammel, M.-T. Leccia, F. Lesueur, E. Mahé, L. Martin, E. Maubec, A. Remenieras, S. Richard, C. Robert, N. Soufir, D. Stoppa-Lyonnet, L. Thomas, P. Vabres, and B. Bressac- de Paillerets, “Recommandations pour le diagnostic de prédisposition génétique au mélanome cutané et pour la prise en charge des personnes à risque,” Annales de Dermatologie et de Vénéréologie, 2014. View at Publisher · View at Google Scholar
  • Annunziata D'Alessandro, and Giovanni De Pergola, “Mediterranean Diet Pyramid: A Proposal for Italian People,” Nutrients, vol. 6, no. 10, pp. 4302–4316, 2014. View at Publisher · View at Google Scholar
  • Nan Jiang, Rongtong Sun, and Qing Sun, “Leptin signaling molecular actions and drug target in hepatocellular carcinoma,” Drug Design Development and Therapy, vol. 8, pp. 2295–2302, 2014. View at Publisher · View at Google Scholar
  • Cheryl D. Toner, “Communicating clinical research to reduce cancer risk through diet: Walnuts as a case example,” Nutrition Research and Practice, vol. 8, no. 4, pp. 347, 2014. View at Publisher · View at Google Scholar
  • Buenaventura Brito Díaz, Itahisa Marcelino Rodríguez, Delia Almeida González, María del Cristo Rodríguez Pérez, and Antonio Cabrera de León, “An Overview of Leptin and the Th1/Th2 Balance,” Open Journal of Immunology, vol. 04, no. 02, pp. 42–50, 2014. View at Publisher · View at Google Scholar
  • Ping-Ping Wang, Xiao-Yan He, Robin Wang, Zengfang Wang, and Yan-Gang Wang, “High Leptin Level is an Independent Risk Factor of Endometrial Cancer: A Meta-Analysis,” Cellular Physiology And Biochemistry, vol. 34, no. 5, pp. 1477–1484, 2014. View at Publisher · View at Google Scholar
  • Joanna Kruk, “Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer,” Asian Pacific Journal Of Cancer Prevention, vol. 15, no. 22, pp. 9579–9586, 2014. View at Publisher · View at Google Scholar
  • Ersilia Nigro, Olga Scudiero, Maria Ludovica Monaco, Alessia Palmieri, Gennaro Mazzarella, Ciro Costagliola, Andrea Bianco, and Aurora Daniele, “New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases,” BioMed Research International, vol. 2014, pp. 1–14, 2014. View at Publisher · View at Google Scholar
  • Sonia Ratib, Kate M Fleming, Colin J Crooks, Alex J Walker, and Joe West, “Causes of Death in People with Liver Cirrhosis in England Compared with the General Population: A Population-Based Cohort Study,” The American Journal of Gastroenterology, 2015. View at Publisher · View at Google Scholar
  • A Salehi-Abargouei, F Akbari, N Bellissimo, and L Azadbakht, “Dietary diversity score and obesity: a systematic review and meta-analysis of observational studies,” European Journal of Clinical Nutrition, 2015. View at Publisher · View at Google Scholar
  • James E. Klaunig, Wolfgang Dekant, Kathy Plotzke, and Anthony R. Scialli, “Biological Relevance of Decamethylcyclopentasiloxane (D5) induced rat uterine endometrial adenocarcinoma tumorigenesis: mode of action and relevance to humans,” Regulatory Toxicology and Pharmacology, 2015. View at Publisher · View at Google Scholar
  • James Charles Hopkins, and Richard Welbourn, “Long-Term Outcomes of Obesity Surgery and Implications for Health System Planning,” Current Obesity Reports, 2015. View at Publisher · View at Google Scholar
  • Amalia Karahalios, Dallas R. English, and Julie A. Simpson, “Weight Change and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis,” American Journal Of Epidemiology, vol. 181, no. 11, pp. 832–845, 2015. View at Publisher · View at Google Scholar
  • M. De Hert, J. Peuskens, T. Sabbe, A. J. Mitchell, B. Stubbs, P. Neven, H. Wildiers, and J. Detraux, “Relationship between prolactin, breast cancer risk, and antipsychotics in patients with schizophrenia: a critical review,” Acta Psychiatrica Scandinavica, 2015. View at Publisher · View at Google Scholar
  • Matthew P. Humphries, V. Craig Jordan, and Valerie Speirs, “Obesity and male breast cancer: provocative parallels?,” BMC Medicine, vol. 13, no. 1, 2015. View at Publisher · View at Google Scholar
  • Shoulei Liang, Zhiwu Ren, Xiuxin Han, Jilong Yang, Luling Shan, Lin Li, Binying Wang, Qianyi Zhang, Tianyang Mu, Kexin Chen, Shunbin Xiong, and Guowen Wang, “PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis,” Plos One, vol. 10, no. 5, 2015. View at Publisher · View at Google Scholar
  • Esther de Vries, Ivan Arroyave, Constanza Pardo, Carolina Wiesner, Raul Murillo, David Forman, Alex Burdorf, and Mauricio Avendano, “Trends in inequalities in premature cancer mortality by educational level in Colombia, 1998-2007,” Journal Of Epidemiology And Community Health, vol. 69, no. 5, pp. 408–415, 2015. View at Publisher · View at Google Scholar
  • Shingo Nakajima, Tohru Hira, and Hiroshi Hara, “Postprandial glucagon-like peptide-1 secretion is increased during the progression of glucose intolerance and obesity in high-fat/high-sucrose diet-fe,” British Journal Of Nutrition, vol. 113, no. 9, pp. 1477–1488, 2015. View at Publisher · View at Google Scholar
  • Veronika Tomankova, Barbora Liskova, Lenka Skalova, Hana Bartikova, Iva Bousova, Lenka Jourova, Pavel Anzenbacher, Jitka Ulrichova, and Eva Anzenbacherova, “Altered cytochrome P450 activities and expression levels in liver and intestines of monosodium glutamate-induced mouse model of human obesity,” Life Sciences, 2015. View at Publisher · View at Google Scholar
  • Isabell Ge, Anja Rudolph, Nitin Shivappa, Dieter Flesch-Janys, James R. Hébert, and Jenny Chang-Claude, “Dietary inflammation potential and postmenopausal breast cancer risk in a German case-control study,” The Breast, 2015. View at Publisher · View at Google Scholar
  • Xu Ding, Dongyi Zheng, Chaonan Fan, Zhaoqiu Liu, Hua Dong, Yuanyuan Lu, and Kemin Qi, “Genome-wide screen of DNA methylation identifies novel markers in childhood obesity,” Gene, 2015. View at Publisher · View at Google Scholar
  • Denise K. Reaves, Erika Ginsburg, John J. Bang, and Jodie M. Fleming, “Persistent organic pollutants and obesity: are they potential mechanisms for breast cancer promotion?,” Endocrine-Related Cancer, vol. 22, no. 2, pp. R69–R86, 2015. View at Publisher · View at Google Scholar
  • Niloofar Taghizadeh, H. Marike Boezen, Jan P. Schouten, Carolien P. Schroder, E. G. Elisabeth de Vries, and Judith M. Vonk, “BMI and Lifetime Changes in BMI and Cancer Mortality Risk,” Plos One, vol. 10, no. 4, 2015. View at Publisher · View at Google Scholar
  • Rowan T. Chlebowski, Joanne E. Schottinger, Jiaxiao Shi, Joanie Chung, and Reina Haque, “Aromatase inhibitors, tamoxifen, and endometrial cancer in breast cancer survivors,” Cancer, 2015. View at Publisher · View at Google Scholar
  • H. Ungefroren, F. Gieseler, and H. Lehnert, “Adipositas und Krebs,” Der Internist, 2015. View at Publisher · View at Google Scholar
  • Sabina Rinaldi, Carine Biessy, Maria de la Luz Hernandez, Martin Lajous, Eduardo Ortiz-Panozo, Elsa Yunes, Ruy Lopez-Ridaura, Gabriela Torres-Mejia, and Isabelle Romieu, “Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers’ Cohort (MTC, ESMaestras),” Cancer Causes & Control, 2015. View at Publisher · View at Google Scholar
  • Fabian Sanchis-Gomar, Alejandro Lucia, Thomas Yvert, Ana Ruiz-Casado, Helios Pareja-Galeano, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Nuria Garatachea, Giuseppe Lippi, Claude Bouchard, and Nathan A. Berger, “Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis,” Cancer Prevention Research, vol. 8, no. 2, pp. 105–110, 2015. View at Publisher · View at Google Scholar
  • Pawel Jozwiak, Anna Krzeslak, Magdalena Brys, and Anna Lipinska, “Glucose-dependent glucose transporter 1 expression and its impact on viability of thyroid cancer cells,” Oncology Reports, vol. 33, no. 2, pp. 913–920, 2015. View at Publisher · View at Google Scholar
  • Amy L. Strong, Matthew E. Burow, Jeffrey M. Gimble, and Bruce A. Bunnell, “Concise Review: The Obesity Cancer Paradigm: Exploration of the Interactions and Crosstalk with Adipose Stem Cells,” Stem Cells, vol. 33, no. 2, pp. 318–326, 2015. View at Publisher · View at Google Scholar
  • Kenneth D. Ward, SangNam Ahn, Fawaz Mzayek, Radwan Al Ali, Samer Rastam, Taghrid Asfar, Fouad Fouad, and Wasim Maziak, “The Relationship Between Waterpipe Smoking and Body Weight: Population-Based Findings From Syria,” Nicotine & Tobacco Research, vol. 17, no. 1, pp. 34–40, 2015. View at Publisher · View at Google Scholar
  • Dorota Diakowska, Krzysztof Grabowski, Mirosław Nienartowicz, Paweł Zarębski, Kamila Fudalej, and Krystyna Markocka-Mączka, “Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer,” Gastroenterology Research and Practice, vol. 2015, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  • Seher Balaban, Lisa S. Lee, Mark Schreuder, and Andrew J. Hoy, “Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?,” BioMed Research International, vol. 2015, pp. 1–17, 2015. View at Publisher · View at Google Scholar