Altered Hepatic Lipid Metabolism Contributes to Nonalcoholic Fatty Liver Disease in Leptin-Deficient Ob/Ob Mice
Figure 4
Ob/Ob mice exhibit increased hepatic mitochondrial gene expression but reduced hepatic mitochondrial protein content. Age-matched 14-week-old male Ob/Ob mice have increased gene expression of hepatic mitochondrial markers (a), while protein content of the hepatic mitochondrial oxidative phosphorylation complexes I to V of the electron transport chain (b) was reduced as compared to wild-type (WT) mice. Values are means SE (); *.
