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Journal of Obesity
Volume 2013 (2013), Article ID 296537, 8 pages
Altered Hepatic Lipid Metabolism Contributes to Nonalcoholic Fatty Liver Disease in Leptin-Deficient Ob/Ob Mice
1Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA
2Department of Food Science, University of Missouri, Columbia, MO 65211, USA
3Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, Columbia, MO 65211, USA
4Harry S. Truman Memorial Veterans' Medical Center, Columbia, MO 65201, USA
Received 2 October 2012; Accepted 17 December 2012
Academic Editor: Ahmed Almobarak
Copyright © 2013 James W. Perfield II et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. D. Browning, L. S. Szczepaniak, R. Dobbins et al., “Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity,” Hepatology, vol. 40, no. 6, pp. 1387–1395, 2004.
- R. S. Rector, J. P. Thyfault, Y. Wei, and J. A. Ibdah, “Non-alcoholic fatty liver disease and the metabolic syndrome: an update,” World Journal of Gastroenterology, vol. 14, no. 2, pp. 185–192, 2008.
- K. Cusi, “Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications,” Gastroenterology, vol. 142, no. 4, pp. 711–725, 2012.
- L. Hebbard and J. George, “Animal models of nonalcoholic fatty liver disease,” Nature Reviews Gastroenterology and Hepatology, vol. 8, no. 1, pp. 34–44, 2011.
- R. M. London and J. George, “Pathogenesis of NASH: animal models,” Clinics in Liver Disease, vol. 11, no. 1, pp. 55–74, 2007.
- Y. Takahashi, Y. Soejima, and T. Fukusato, “Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis,” World Journal of Gastroenterology, vol. 18, no. 19, pp. 2300–2308, 2012.
- R. S. Rector, J. P. Thyfault, G. M. Uptergrove et al., “Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model,” Journal of Hepatology, vol. 52, no. 5, pp. 727–736, 2010.
- M. Tschöp and M. L. Heiman, “Rodent obesity models: an overview,” Experimental and Clinical Endocrinology and Diabetes, vol. 109, no. 6, pp. 307–319, 2001.
- G. Wolf, “Insulin resistance associated with leptin deficiency in mice: a possible model for noninsulin-dependent diabetes mellitus,” Nutrition Reviews, vol. 59, no. 6, pp. 177–179, 2001.
- J. Xu, S. R. Kulkarni, A. C. Donepudi, V. R. More, and A. L. Slitt, “Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice,” Diabetes, vol. 61, no. 12, pp. 3208–3218, 2012.
- I. García-Ruiz, C. Rodríguez-Juan, T. Díaz-Sanjuan et al., “Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice,” Hepatology, vol. 44, no. 3, pp. 581–591, 2006.
- J. Monsenego, A. Mansouri, M. Akkaoui et al., “Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis,” Journal of Hepatology, vol. 56, no. 3, pp. 632–639, 2012.
- Q. M. Anstee and R. D. Goldin, “Mouse models in non-alcoholic fatty liver disease and steatohepatitis research,” International Journal of Experimental Pathology, vol. 87, no. 1, pp. 1–16, 2006.
- R. S. Rector, J. P. Thyfault, R. T. Morris et al., “Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 294, no. 3, pp. G619–G626, 2008.
- R. S. Rector, G. M. Uptergrove, E. Matthew Morris et al., “Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 300, no. 5, pp. G874–G883, 2011.
- D. M. Schwartz and N. E. Wolins, “A simple and rapid method to assay triacylglycerol in cells and tissues,” Journal of Lipid Research, vol. 48, no. 11, pp. 2514–2520, 2007.
- R. S. Rector, J. P. Thyfault, M. J. Laye et al., “Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats,” Journal of Physiology, vol. 586, no. 17, pp. 4241–4249, 2008.
- N. Anderson and J. Borlak, “Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis,” Pharmacological Reviews, vol. 60, no. 3, pp. 311–357, 2008.
- A. S. Garfield, C. Patterson, S. Skora et al., “Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract,” Endocrinology, vol. 153, no. 10, pp. 4600–4607, 2012.
- M. W. Schwartz, D. G. Baskin, T. R. Bukowski et al., “Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice,” Diabetes, vol. 45, no. 4, pp. 531–535, 1996.
- V. Trak-Smayra, V. Paradis, J. Massart, S. Nasser, V. Jebara, and B. Fromenty, “Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet,” International Journal of Experimental Pathology, vol. 92, no. 6, pp. 413–421, 2011.
- S. Bellentani, F. Scaglioni, M. Marino, and G. Bedogni, “Epidemiology of non-alcoholic fatty liver disease,” Digestive Diseases, vol. 28, no. 1, pp. 155–161, 2010.
- J. M. Schattenberg and P. R. Galle, “Animal models of non-alcoholic steatohepatitis: of mice and man,” Digestive Diseases, vol. 28, no. 1, pp. 247–254, 2010.
- H. Fujii and N. Kawada, “Inflammation and fibrogenesis in steatohepatitis,” Journal of Gastroenterology, vol. 47, no. 3, pp. 215–225, 2012.
- B. T. Bikman, “A role for sphingolipids in the pathophysiology of obesity-induced inflammation,” Cellular and Molecular Life Sciences, vol. 69, no. 13, pp. 2135–2146, 2012.
- I. Shimomura, Y. Bashmakov, and J. D. Horton, “Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus,” Journal of Biological Chemistry, vol. 274, no. 42, pp. 30028–30032, 1999.
- F. Diraison, P. H. Moulin, and M. Beylot, “Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease,” Diabetes and Metabolism, vol. 29, no. 5, pp. 478–485, 2003.
- K. L. Donnelly, C. I. Smith, S. J. Schwarzenberg, J. Jessurun, M. D. Boldt, and E. J. Parks, “Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease,” Journal of Clinical Investigation, vol. 115, no. 5, pp. 1343–1351, 2005.
- J. M. Schwarz, P. Linfoot, D. Dare, and K. Aghajanian, “Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets,” American Journal of Clinical Nutrition, vol. 77, no. 1, pp. 43–50, 2003.
- R. Dentin, F. Benhamed, I. Hainault et al., “Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice,” Diabetes, vol. 55, no. 8, pp. 2159–2170, 2006.
- K. F. Petersen, S. Dufour, D. Befroy, M. Lehrke, R. E. Hendler, and G. I. Shulman, “Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes,” Diabetes, vol. 54, no. 3, pp. 603–608, 2005.
- K. M. Utzschneider and S. E. Kahn, “Review: the role of insulin resistance in nonalcoholic fatty liver disease,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 12, pp. 4753–4761, 2006.
- Y. Wei, R. S. Rector, J. P. Thyfault, and J. A. Ibdah, “Nonalcoholic fatty liver disease and mitochondrial dysfunction,” World Journal of Gastroenterology, vol. 14, no. 2, pp. 193–199, 2008.
- P. Cohen, M. Miyazaki, N. D. Socci et al., “Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss,” Science, vol. 297, no. 5579, pp. 240–243, 2002.
- S. B. Biddinger, M. Miyazaki, J. Boucher, J. M. Ntambi, and C. R. Kahn, “Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c,” Diabetes, vol. 55, no. 7, pp. 2032–2041, 2006.
- T. R. Koves, P. Li, J. An et al., “Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency,” Journal of Biological Chemistry, vol. 280, no. 39, pp. 33588–33598, 2005.
- J. P. Thyfault, M. G. Cree, D. Zheng et al., “Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism,” American Journal of Physiology-Cell Physiology, vol. 292, no. 2, pp. C729–C739, 2007.
- T. Aureli, C. Puccetti, M. E. Di Cocco et al., “Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis. A study by 13C NMR spectroscopy in conscious, freely moving rats,” European Journal of Biochemistry, vol. 263, no. 1, pp. 287–293, 1999.